HistoGeneX (Belgium)

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Title DOI
https://doi.org/10.1038/nm.4292 HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
https://doi.org/10.1056/nejmoa1105358 RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
https://doi.org/10.1016/j.jtho.2018.05.013 PD-L1 Immunohistochemistry Comparability Study in Real-Life Clinical Samples: Results of Blueprint Phase 2 Project
https://doi.org/10.1007/s10456-018-9613-x Consensus guidelines for the use and interpretation of angiogenesis assays
https://doi.org/10.1038/s41591-019-0628-7 Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial
https://doi.org/10.1161/01.cir.0000026393.47805.21 Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques
https://doi.org/10.1038/s41571-019-0181-9 Vessel co-option in cancer
https://doi.org/10.1073/pnas.1802166115 Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)
https://doi.org/10.1016/s0008-6363(01)00290-5 Apoptotic versus autophagic cell death in heart failure
https://doi.org/10.1038/bjc.2017.334 International consensus guidelines for scoring the histopathological growth patterns of liver metastasis
https://doi.org/10.1002/path.5406 The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers in breast cancer clinical trials and daily practice
https://doi.org/10.1016/j.nbd.2014.08.032 Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
https://doi.org/10.1152/ajpheart.00523.2005 Mesenchymal stem cell adhesion to cardiac microvascular endothelium: activators and mechanisms
https://doi.org/10.1016/j.jacc.2006.09.047 Selective Clearance of Macrophages in Atherosclerotic Plaques by Autophagy
https://doi.org/10.1158/1541-7786.mcr-05-0121 p53-Independent Regulation of p21Waf1/Cip1 Expression and Senescence by Chk2
https://doi.org/10.1016/s2352-3026(20)30123-x Effect of the COVID-19 pandemic on cancer treatment and research
https://doi.org/10.1016/j.molmed.2007.08.004 Autophagy in cardiovascular disease
https://doi.org/10.1038/nrc.2018.14 Non-angiogenic tumours and their influence on cancer biology
https://doi.org/10.1155/2018/7687083 Defective Autophagy in Atherosclerosis: To Die or to Senesce?
https://doi.org/10.1186/s13195-017-0329-8 Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology
https://doi.org/10.1369/jhc.5a6743.2005 In Situ Detection of Starvation-induced Autophagy
https://doi.org/10.1038/modpathol.3800774 Standardization of HER2 testing: results of an international proficiency-testing ring study
https://doi.org/10.1007/s10456-019-09661-5 Angiogenic desmoplastic histopathological growth pattern as a prognostic marker of good outcome in patients with colorectal liver metastases
https://doi.org/10.1093/cercor/bhp133 Vesicular Glutamate Transporter VGLUT1 Has a Role in Hippocampal Long-Term Potentiation and Spatial Reversal Learning
https://doi.org/10.1136/jcp.2009.066548 EGFR fluorescence in situ hybridisation assay: guidelines for application to non-small-cell lung cancer
https://doi.org/10.1093/jnci/djx066 Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses
https://doi.org/10.1136/esmoopen-2018-000398 Multidisciplinary molecular tumour board: a tool to improve clinical practice and selection accrual for clinical trials in patients with cancer
https://doi.org/10.1016/s1885-5857(09)72225-x Quantitative Ex Vivo and In Vivo Comparison of Lumen Dimensions Measured by Optical Coherence Tomography and Intravascular Ultrasound in Human Coronary Arteries
https://doi.org/10.1016/s0300-8932(09)71328-4 Comparación cuantitativa ex vivo e in vivo de las dimensiones del lumen medidas por tomografía de coherencia óptica y ecografía intravascular en arterias coronarias humanas
https://doi.org/10.1007/s00262-020-02618-4 A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases
https://doi.org/10.1002/cjp2.105 Replacement and desmoplastic histopathological growth patterns: A pilot study of prediction of outcome in patients with uveal melanoma liver metastases
https://doi.org/10.1002/cjp2.161 Replacement and desmoplastic histopathological growth patterns in cutaneous melanoma liver metastases: frequency, characteristics, and robust prognostic value
https://doi.org/10.1038/s41379-021-00865-z Interobserver variability in the assessment of stromal tumor-infiltrating lymphocytes (sTILs) in triple-negative invasive breast carcinoma influences the association with pathological complete response: the IVITA study
https://doi.org/10.1038/s41416-020-0948-x Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy
https://doi.org/10.1111/his.13056 Validated programmed cell death ligand 1 immunohistochemistry assays (E1L3N and SP142) reveal similar immune cell staining patterns in melanoma when using the same sensitive detection system
https://doi.org/10.1136/esmoopen-2018-000464 Phase I clinical trial of decitabine (5-aza-2'-deoxycytidine) administered by hepatic arterial infusion in patients with unresectable liver-predominant metastases
https://doi.org/10.1007/s40487-020-00124-2 Cancer Treatment and Research During the COVID-19 Pandemic: Experience of the First 6 Months
https://doi.org/10.1161/01.res.0000020017.84398.61 Platelet Phagocytosis and Processing of β-Amyloid Precursor Protein as a Mechanism of Macrophage Activation in Atherosclerosis
https://doi.org/10.1111/j.1752-0606.2002.tb00371.x CONSTRUCTIVE HYPOTHESIZING, DIALOGIC UNDERSTANDING AND THE THERAPIST'S INNER CONVERSATION: SOME IDEAS ABOUT KNOWING AND NOT KNOWING IN THE FAMILY THERAPY SESSION
https://doi.org/10.1007/s00415-011-6031-z Asymptomatic small fiber neuropathy in diabetes mellitus: investigations with intraepidermal nerve fiber density, quantitative sensory testing and laser-evoked potentials
https://doi.org/10.1038/sj.bjc.6604025 R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies
https://doi.org/10.1186/s13058-019-1108-1 Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression
https://doi.org/10.1038/sj.npp.1301431 IMPA1 is Essential for Embryonic Development and Lithium-Like Pilocarpine Sensitivity
https://doi.org/10.1002/ccd.21310 Three‐dimensional and quantitative analysis of atherosclerotic plaque composition by automated differential echogenicity
https://doi.org/10.1016/j.semcancer.2018.01.009 Histopathological growth patterns as a candidate biomarker for immunomodulatory therapy
https://doi.org/10.1016/s0002-9440(10)63346-9 Vitamin D3 Induces Caspase-14 Expression in Psoriatic Lesions and Enhances Caspase-14 Processing in Organotypic Skin Cultures
https://doi.org/10.1038/s41416-020-0812-z Immune phenotype and histopathological growth pattern in patients with colorectal liver metastases
https://doi.org/10.18632/oncotarget.4723 BRAF mutation testing with a rapid, fully integrated molecular diagnostics system
https://doi.org/10.1371/journal.pone.0161496 Development and Validation of a Histological Method to Measure Microvessel Density in Whole-Slide Images of Cancer Tissue
https://doi.org/10.1016/s0735-1097(02)02122-8 Deoxyribonucleic acid damage/repairproteins are elevated in the failing human myocardium due to idiopathic dilated cardiomyopathy
https://doi.org/10.1186/1756-0500-7-337 Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: implications for anti-EGFR treatment response
https://doi.org/10.1186/s13104-016-2085-4 Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?
https://doi.org/10.1038/s41379-019-0367-9 Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study
https://doi.org/10.1016/j.semcancer.2020.07.002 Can medical imaging identify the histopathological growth patterns of liver metastases?
https://doi.org/10.1136/jclinpath-2019-205970 Rapid clinical mutational testing of KRAS, BRAF and EGFR: a prospective comparative analysis of the Idylla technique with high-throughput next-generation sequencing
https://doi.org/10.3390/cancers13020168 A Comprehensive Analysis of Baseline Clinical Characteristics and Biomarkers Associated with Outcome in Advanced Melanoma Patients Treated with Pembrolizumab
https://doi.org/10.5858/arpa.2017-0159-oa Optimal Evaluation of Programmed Death Ligand-1 on Tumor Cells Versus Immune Cells Requires Different Detection Methods
https://doi.org/10.1186/s12967-016-0990-x Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients
https://doi.org/10.1093/annonc/mdv514.13 PD-L1 IHC validation and comparison of E1L3N & SP142 mAbs in melanoma
https://doi.org/10.3390/cancers12061461 PDX1 DNA Methylation Distinguishes Two Subtypes of Pancreatic Neuroendocrine Neoplasms with a Different Prognosis
https://doi.org/10.1371/journal.pone.0069210 Alveolarization Genes Modulated by Fetal Tracheal Occlusion in the Rabbit Model for Congenital Diaphragmatic Hernia: A Randomized Study
https://doi.org/10.1200/jco.2012.30.15_suppl.8503 Analysis of molecular mechanisms of response and resistance to vemurafenib (vem) in BRAFV600E melanoma.
https://doi.org/10.1002/cjp2.152 Biomarker recommendation for PD‐1/PD‐L1 immunotherapy development in pediatric cancer based on digital image analysis of PD‐L1 and immune cells
https://doi.org/10.3389/fchem.2021.640566 In Vitro and In Situ Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes
https://doi.org/10.1158/1538-7445.sabcs19-pd1-07 Abstract PD1-07: Exploratory analytical harmonization of PD-L1 immunohistochemistry assays in advanced triple-negative breast cancer: A retrospective substudy of IMpassion130
https://doi.org/10.1158/2326-6066.cir-19-0568 Tumor Fusion Burden as a Hallmark of Immune Infiltration in Prostate Cancer
https://doi.org/10.1038/s41523-020-0155-1 Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
https://doi.org/10.1016/j.tranon.2020.100984 Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies
https://doi.org/10.3390/cancers13194910 Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group
https://doi.org/10.1200/go.20.00346 Reimagining Global Oncology Clinical Trials for the Postpandemic Era: A Call to Arms
https://doi.org/10.1200/jco.2015.33.15_suppl.3015 Molecular, immune and histopathological characterization of NSCLC based on PDL1 expression on tumor and immune cells and association with response to the anti-PDL1 antibody MPDL3280A.
https://doi.org/10.1158/1535-7163.mct-06-0112 Real-time gene expression analysis in human xenografts for evaluation of histone deacetylase inhibitors
https://doi.org/10.1049/icp.2022.0871 WEcharge: democratizing EV charging infrastructure
https://doi.org/10.1200/jco.2015.33.15_suppl.11054 Immune response triggered by a novel molecular crosstalk of major hallmarks of cancer: Angiogenesis, mismatch repair, and immune pathways.
https://doi.org/10.1007/s11222-025-10604-y Two-level D- and A-optimal main-effects designs with run sizes one and two more than a multiple of four
https://doi.org/10.1159/000081098 Alteration of Frizzled Expression in Renal Cell Carcinoma
https://doi.org/10.1159/000082723 Smooth Muscle Cell Hypertrophy in Varicose Veins Is Associated with Expression of Estrogen Receptor-β
https://doi.org/10.1016/j.semcancer.2017.10.004 Genito-urinary genomics and emerging biomarkers for immunomodulatory cancer treatment
https://doi.org/10.1002/ppul.22512 Signaling molecules in the fetal rabbit model for congenital diaphragmatic hernia
https://doi.org/10.1080/23808993.2016.1140005 Challenges & Perspectives of Immunotherapy Biomarkers & The HistoOncoImmune™ Methodology
https://doi.org/10.1016/j.jim.2004.01.013 Flow cytometric evaluation of a model for phagocytosis of cells undergoing apoptosis
https://doi.org/10.1002/path.1525 Western blot analysis of a limited number of cells: a valuable adjunct to proteome analysis of paraffin wax‐embedded, alcohol‐fixed tissue after laser capture microdissection
https://doi.org/10.1093/annonc/mdx489 An exploratory, open-label, randomized, multicenter study to investigate the pharmacodynamics of a glycoengineered antibody (imgatuzumab) and cetuximab in patients with operable head and neck squamous cell carcinoma
https://doi.org/10.1111/j.1476-5381.2012.01878.x The cholecystokinin CCK2 receptor antagonist, JNJ‐26070109, inhibits gastric acid secretion and prevents omeprazole‐induced acid rebound in the rat
https://doi.org/10.1016/j.ijcard.2008.12.078 Stent thrombosis is not always stent thrombosis: De novo atherosclerosis in a stented coronary segment
https://doi.org/10.1016/j.expneurol.2017.02.009 Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice
https://doi.org/10.1200/jco.2017.35.15_suppl.3028 Epitope mapping of PD-L1 primary antibodies (28-8, SP142, SP263, E1L3N).
https://doi.org/10.1586/14737159.2015.993972 Predictive tissue biomarkers for bevacizumab-containing therapy in metastatic colorectal cancer: an update
https://doi.org/10.1177/0091270010361254 The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of RO5068760, an MEK Inhibitor, in Healthy Volunteers: Assessment of Target Suppression
https://doi.org/10.1371/journal.pone.0220906 HER-2 status of circulating tumor cells in a metastatic breast cancer cohort: A comparative study on characterization techniques
https://doi.org/10.3390/jcm9103090 Absence of BCL-2 Expression Identifies a Subgroup of AML with Distinct Phenotypic, Molecular, and Clinical Characteristics
https://doi.org/10.1016/j.jtho.2018.08.543 MA26.07 ROS1 (SP384) Immunohistochemistry Inter-Reader Precision Between 12 Pathologists
https://doi.org/10.1200/jco.2020.38.15_suppl.3086 The spatial localization of CD163+ tumor-associated macrophages predicts prognosis and response to therapy in inflammatory breast cancer.
https://doi.org/10.1016/s0002-9440(10)63869-2 Overexpression of the Anti-Apoptotic Caspase-2 Short Isoform in Macrophage-Derived Foam Cells of Human Atherosclerotic Plaques
https://doi.org/10.1016/j.bbr.2013.01.042 Haploinsufficiency of VGluT1 but not VGluT2 impairs extinction of spatial preference and response suppression
JNJ-26854165 - a novel hdm2 antagonist in clinical development showing broad-spectrum preclinical antitumor activity against solid malignancies
https://doi.org/10.1080/23808993.2017.1281737 Digital pathology in immuno-oncology – a roadmap for clinical development
https://doi.org/10.1158/1538-7445.am10-3628 Abstract 3628: JNJ-38877605: A selective oral Met inhibitor for the treatment of cancer
https://doi.org/10.1159/000064514 A Three-Dimensional Quantitative Analysis of Restenosis Parameters after Balloon Angioplasty: Comparison between Semi-Automatic Computer-Assisted Planimetry and Stereology
https://doi.org/10.1158/1538-7445.sabcs19-pd5-02 Abstract PD5-02: Effective and globally reproducible digital pathologist training program on PD-L1 immunohistochemistry scoring on immune cells as a predictive biomarker for cancer immunotherapy in triple negative breast cancer