VIB-KU Leuven Center for Brain & Disease Research

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Title DOI
https://doi.org/10.1038/nmeth.4463 SCENIC: single-cell regulatory network inference and clustering
https://doi.org/10.1038/s41593-020-00783-4 Reactive astrocyte nomenclature, definitions, and future directions
https://doi.org/10.1016/j.tcb.2018.02.004 Protein Phase Separation: A New Phase in Cell Biology
https://doi.org/10.1038/s41564-018-0337-x The neuroactive potential of the human gut microbiota in quality of life and depression
https://doi.org/10.1038/s41591-018-0096-5 Phenotype molding of stromal cells in the lung tumor microenvironment
https://doi.org/10.1038/s41588-018-0058-3 Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
https://doi.org/10.1016/j.cell.2022.12.032 Hallmarks of neurodegenerative diseases
https://doi.org/10.1038/s41596-020-0336-2 A scalable SCENIC workflow for single-cell gene regulatory network analysis
https://doi.org/10.1056/nejmoa1804355 MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset
https://doi.org/10.1111/ene.14393 Amyotrophic lateral sclerosis: a clinical review
https://doi.org/10.1126/science.abf4588 Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
https://doi.org/10.1016/j.celrep.2019.03.099 The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
https://doi.org/10.1016/j.cell.2018.05.057 A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
https://doi.org/10.1016/j.cell.2020.06.038 Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease
https://doi.org/10.1126/science.1261498 Patterns and ecological drivers of ocean viral communities
https://doi.org/10.1126/science.abk2432 Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly
https://doi.org/10.1038/s41467-019-14198-8 Identification of region-specific astrocyte subtypes at single cell resolution
https://doi.org/10.1056/nejmoa1813959 Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source
https://doi.org/10.15252/embj.201797397 APP mouse models for Alzheimer's disease preclinical studies
https://doi.org/10.1016/j.cell.2018.06.025 Toward Minimal Residual Disease-Directed Therapy in Melanoma
https://doi.org/10.1038/s41573-022-00391-w The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
https://doi.org/10.1038/s41593-020-00789-y Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
https://doi.org/10.1016/j.biopsych.2020.02.001 The β-Secretase BACE1 in Alzheimer’s Disease
https://doi.org/10.1038/s41588-019-0403-1 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
https://doi.org/10.1038/nn.4085 Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
https://doi.org/10.1038/s41592-023-01938-4 SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks
https://doi.org/10.1093/bioinformatics/bty916 GRNBoost2 and Arboreto: efficient and scalable inference of gene regulatory networks
https://doi.org/10.1016/j.cell.2018.07.048 Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis
https://doi.org/10.1016/j.molcel.2017.02.013 Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
https://doi.org/10.1056/nejmoa2003715 Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
https://doi.org/10.1038/s41588-021-00973-1 Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
https://doi.org/10.1038/s41592-019-0367-1 cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq data
https://doi.org/10.1038/s41593-019-0392-5 Evidence that recurrent circuits are critical to the ventral stream’s execution of core object recognition behavior
https://doi.org/10.1016/s1474-4422(18)30089-9 Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
https://doi.org/10.1038/s41593-020-0602-1 Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
https://doi.org/10.1038/s41586-019-0904-1 Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity
https://doi.org/10.1038/nature26137 A TRP channel trio mediates acute noxious heat sensing
https://doi.org/10.1038/s41467-017-01103-4 A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
https://doi.org/10.1038/nri.2016.151 Homeostasis-altering molecular processes as mechanisms of inflammasome activation
https://doi.org/10.1038/ncomms15295 Tau association with synaptic vesicles causes presynaptic dysfunction
https://doi.org/10.1016/j.cell.2018.03.067 Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation
https://doi.org/10.4049/jimmunol.140.5.1506 Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN- gamma .
https://doi.org/10.1016/j.cell.2021.10.027 Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
https://doi.org/10.1152/physrev.00005.2019 Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
https://doi.org/10.1038/s41467-017-00911-y HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
https://doi.org/10.1136/jnnp-2020-322983 TDP-43 proteinopathies: a new wave of neurodegenerative diseases
https://doi.org/10.1126/science.abb4309 HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
https://doi.org/10.1016/j.neuron.2012.08.022 LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis
https://doi.org/10.1016/j.cell.2020.06.026 Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
https://doi.org/10.1016/s1474-4422(18)30490-3 The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
https://doi.org/10.1016/j.celrep.2020.108189 Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans
https://doi.org/10.1038/s41418-023-01153-w Apoptotic cell death in disease—Current understanding of the NCCD 2023
https://doi.org/10.1016/j.neubiorev.2013.07.014 Age-related differences in attentional cost associated with postural dual tasks: Increased recruitment of generic cognitive resources in older adults
https://doi.org/10.1038/s41586-020-1968-7 ATP13A2 deficiency disrupts lysosomal polyamine export
https://doi.org/10.1038/s41577-024-01104-7 Neuroinflammation in Alzheimer disease
https://doi.org/10.1016/j.neuron.2013.06.039 CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation
https://doi.org/10.1016/s1474-4422(19)30394-1 Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
https://doi.org/10.1016/j.neuron.2016.09.037 A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals
https://doi.org/10.15252/embr.201643426 The ins and outs of endoplasmic reticulum‐controlled lipid biosynthesis
https://doi.org/10.15252/emmm.201910606 Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
https://doi.org/10.1038/s41586-020-03118-2 Local immune response to food antigens drives meal-induced abdominal pain
https://doi.org/10.1038/s41593-019-0525-x Stem-cell-derived human microglia transplanted in mouse brain to study human disease
https://doi.org/10.1038/s41598-019-41200-6 Acceptance of immersive head-mounted virtual reality in older adults
https://doi.org/10.1016/j.cell.2016.05.020 Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool
https://doi.org/10.1038/ng.3626 NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
https://doi.org/10.1016/j.stem.2022.11.004 A reference human induced pluripotent stem cell line for large-scale collaborative studies
https://doi.org/10.1038/srep20877 Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD
https://doi.org/10.1016/j.celrep.2016.09.063 Loss of Bin1 Promotes the Propagation of Tau Pathology
https://doi.org/10.1161/strokeaha.119.028337 Review of Perfusion Imaging in Acute Ischemic Stroke
https://doi.org/10.1038/s41556-020-0547-3 Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma
https://doi.org/10.1093/nar/gkr996 SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants
https://doi.org/10.1126/science.aba9760 Mitochondrial dynamics in postmitotic cells regulate neurogenesis
https://doi.org/10.1126/science.aao4827 Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
https://doi.org/10.1126/science.abn4705 Mitochondria metabolism sets the species-specific tempo of neuronal development
https://doi.org/10.1038/s41583-021-00431-1 Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation
https://doi.org/10.1038/s41593-023-01257-z Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease
https://doi.org/10.1038/s41467-019-09671-3 Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
https://doi.org/10.1007/s00401-018-1835-x Energy metabolism in ALS: an underappreciated opportunity?
https://doi.org/10.7554/elife.48175 Ten common statistical mistakes to watch out for when writing or reviewing a manuscript
https://doi.org/10.1016/j.molcel.2020.10.032 Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis
https://doi.org/10.1016/j.neuron.2017.02.001 Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
https://doi.org/10.1093/brain/aws339 Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
https://doi.org/10.1093/bfgp/elx046 Mapping gene regulatory networks from single-cell omics data
https://doi.org/10.1016/j.neuron.2018.01.022 Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau
https://doi.org/10.1016/j.cell.2017.07.004 Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions
https://doi.org/10.1093/eurheartj/ehz120 Early goal-directed haemodynamic optimization of cerebral oxygenation in comatose survivors after cardiac arrest: the Neuroprotect post-cardiac arrest trial
https://doi.org/10.1038/s41586-020-2857-9 Macrophage-derived glutamine boosts satellite cells and muscle regeneration
https://doi.org/10.1186/s13024-019-0323-7 Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
https://doi.org/10.1038/s41598-021-84127-7 The impact of the COVID-19 pandemic on wellbeing and cognitive functioning of older adults
https://doi.org/10.1038/s41467-018-04376-5 A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation
https://doi.org/10.1038/s41586-022-05242-7 A cellular hierarchy in melanoma uncouples growth and metastasis
https://doi.org/10.1016/j.neuron.2020.07.040 Integrative Benchmarking to Advance Neurally Mechanistic Models of Human Intelligence
https://doi.org/10.1038/s41593-020-0619-5 Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72
https://doi.org/10.1038/s41467-021-24082-z Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
https://doi.org/10.1038/s41467-020-20430-7 Benchmarking joint multi-omics dimensionality reduction approaches for the study of cancer
https://doi.org/10.1016/j.cell.2011.02.039 Loss of Skywalker Reveals Synaptic Endosomes as Sorting Stations for Synaptic Vesicle Proteins
https://doi.org/10.7554/elife.35878 Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
https://doi.org/10.1016/j.neuroimage.2019.116278 Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis
https://doi.org/10.15252/embj.201695773 The SAC 1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals
https://doi.org/10.1016/j.tins.2021.06.007 Cellular senescence at the crossroads of inflammation and Alzheimer's disease