ActoGeniX (Belgium)

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Title DOI
https://doi.org/10.1038/mi.2009.116 Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
https://doi.org/10.1016/j.chom.2012.02.006 Lactocepin Secreted By Lactobacillus Exerts Anti-Inflammatory Effects By Selectively Degrading Proinflammatory Chemokines
https://doi.org/10.1172/jci60530 Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice
https://doi.org/10.1016/j.mib.2013.06.002 Engineering lactococci and lactobacilli for human health
https://doi.org/10.1007/s12035-011-8175-3 Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives
https://doi.org/10.2337/db13-1236 Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 byLactococcus lactisReverses Diabetes in Recent-Onset NOD Mice
https://doi.org/10.1258/la.2009.009112 Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man
https://doi.org/10.1016/j.oraloncology.2010.04.008 AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis
https://doi.org/10.1002/cncr.28365 Phase 1b, multicenter, single blinded, placebo‐controlled, sequential dose escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer receiving induction chemotherapy
https://doi.org/10.4049/jimmunol.0802891 Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab° Dq8 Transgenic Mice
https://doi.org/10.1186/1475-2859-13-s1-s11 Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case
https://doi.org/10.1111/j.1749-6632.2009.05067.x Actobiotics™ as a Novel Method for Cytokine Delivery
https://doi.org/10.3109/08830180903197498 Modulation of Gut-Associated Lymphoid Tissue Functions with Genetically ModifiedLactococcus lactis
https://doi.org/10.2741/3571 Immunomodulation by genetically engineered lactic acid bacteria
https://doi.org/10.1111/j.1365-2613.2008.00598.x Expression of galectins‐1, ‐3 and ‐4 varies with strain and type of experimental colitis in mice
https://doi.org/10.1111/j.1365-3083.2008.02206.x Genetically Engineered Lactococcus lactis Secreting Murine IL‐10 Modulates the Functions of Bone Marrow‐Derived Dendritic Cells in the Presence of LPS
https://doi.org/10.3920/bm2014.0083 Trimming of two major type 1 diabetes driving antigens, GAD65 and IA-2, allows for successful expression in Lactococcus lactis
https://doi.org/10.1111/j.1742-4658.2012.08581.x Biochemical and pharmacological study of N‐linked glycosylation of the human serotonin 5‐HT7(a) receptor
https://doi.org/10.1200/jco.2009.27.15_suppl.e14570 Effect of a mouth rinse formulation with human trefoil factor 1-secreting Lactococcus lactis in experimental oral mucositis in hamsters
https://doi.org/10.1109/biorob52689.2022.9925448 Experimental Evaluation of a Stiffness-Fault-Tolerant Control Strategy on an Elastic Actuator for Wearable Robotics
https://doi.org/10.1136/gutjnl-2014-307263.177 PTU-103 Intra-luminal Interleukin (il)-27 Is A Potential Future Therapeutic For Inflammatory Bowel Disease
https://doi.org/10.1586/eci.12.55 Clinical development of lactocepin: a novel bacterial biologic?
https://doi.org/10.1016/j.cyto.2013.06.115 112
https://doi.org/10.1016/j.cyto.2010.07.099 PS1-27 Lactococcus lactis expressing IL-27: A potential therapeutic for inflammatory bowel disease
https://doi.org/10.1016/j.cyto.2010.07.048 SS1-1 Lactococcus lactis expressing IL-27: Therapeutic promise in inflammatory bowel disease
https://doi.org/10.1016/j.clim.2009.03.083 OR.71. Combination Therapy of Short-term Low-dose Anti-CD3 and Oral Administration of Genetically-modified Lactococcus Lactis Secreting Insulin and IL-10 Enhances Remission in New-onset Diabetic NOD Mice
https://doi.org/10.1097/00054725-201212001-00209 Mucosal Delivery of IL-27 Attenuates Murine Enterocolitis via T Cell-Derived IL-10
https://doi.org/10.1200/jco.2012.30.15_suppl.9024 Phase Ib, multicenter, single-blinded, placebo-controlled, sequential dose-escalation study to assess the safety and tolerability of topically applied AG013 in subjects with locally advanced head and neck cancer (LAHNC) receiving induction chemotherapy (ICT).