Ablynx (Belgium)

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Title DOI
https://doi.org/10.1038/nbt1359 Control of coleopteran insect pests through RNA interference
https://doi.org/10.1126/science.aar6089 The transcriptional landscape of polyploid wheat
https://doi.org/10.1056/nejmoa1806311 Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura
https://doi.org/10.1038/nbt1126 Selecting and screening recombinant antibody libraries
https://doi.org/10.1007/s00253-007-1142-2 Properties, production, and applications of camelid single-domain antibody fragments
https://doi.org/10.1007/s00401-021-02275-6 Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology
https://doi.org/10.1073/pnas.0505379103 Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies
https://doi.org/10.1016/j.ccr.2011.12.029 Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells
https://doi.org/10.1016/j.tplants.2010.08.009 The roots of a new green revolution
https://doi.org/10.1186/gb-2013-14-1-r4 Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice
https://doi.org/10.1016/j.nhtm.2014.08.001 Animal models in translational medicine: Validation and prediction
https://doi.org/10.1016/j.molcel.2015.07.032 NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
https://doi.org/10.1038/s41591-022-02074-w Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring
https://doi.org/10.1038/cdd.2011.164 Many stimuli pull the necrotic trigger, an overview
https://doi.org/10.1158/0008-5472.can-08-3255 Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis
https://doi.org/10.1172/jci97911 Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans
https://doi.org/10.1007/s00262-006-0180-4 Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies
https://doi.org/10.2174/156652408784221306 Molecular Mechanisms and Pathophysiology of Necrotic Cell Death
https://doi.org/10.1016/j.jalz.2016.09.014 Blood‐based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic
https://doi.org/10.1002/art.21827 Formatted anti–tumor necrosis factor α VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen‐induced arthritis
https://doi.org/10.1021/acssuschemeng.9b01378 Degradation of Deep-Eutectic Solvents Based on Choline Chloride and Carboxylic Acids
https://doi.org/10.1002/marc.201200689 Chemistry of Crosslinking Processes for Self‐Healing Polymers
https://doi.org/10.1002/anie.202216719 Pyrene‐Based Covalent Organic Frameworks for Photocatalytic Hydrogen Peroxide Production
https://doi.org/10.1158/1535-7163.mct-07-2384 Improved tumor targeting of anti–epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology
https://doi.org/10.1128/aac.01802-15 Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection
https://doi.org/10.1038/mi.2009.116 Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis
https://doi.org/10.1016/j.cemconcomp.2014.07.014 X-ray computed tomography proof of bacterial-based self-healing in concrete
https://doi.org/10.1002/ijc.26145 A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth
https://doi.org/10.1124/dmd.107.015644 Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
https://doi.org/10.1038/s41467-018-05846-6 Nanophotonic Pockels modulators on a silicon nitride platform
https://doi.org/10.1007/s40571-020-00354-1 Grand challenges for Smoothed Particle Hydrodynamics numerical schemes
https://doi.org/10.1111/pce.12622 Mesophyll conductance to CO2 and Rubisco as targets for improving intrinsic water use efficiency in C3 plants
https://doi.org/10.1073/pnas.1012865107 CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells
https://doi.org/10.1021/ct300902c A New Mean-Field Method Suitable for Strongly Correlated Electrons: Computationally Facile Antisymmetric Products of Nonorthogonal Geminals
https://doi.org/10.1007/s10585-007-9114-6 Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer
https://doi.org/10.1186/1475-2859-9-49 The HAC1 gene from Pichia pastoris: characterization and effect of its overexpression on the production of secreted, surface displayed and membrane proteins
https://doi.org/10.1016/j.pharmthera.2015.07.007 CD70: An emerging target in cancer immunotherapy
https://doi.org/10.2967/jnumed.107.048538 Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT
https://doi.org/10.1016/j.conbuildmat.2015.12.186 Comparison of different approaches for self-healing concrete in a large-scale lab test
https://doi.org/10.1002/alz.12841 Plasma and CSF biomarkers in a memory clinic: Head‐to‐head comparison of phosphorylated tau immunoassays
https://doi.org/10.1038/emboj.2011.85 T‐cell receptor‐induced JNK activation requires proteolytic inactivation of CYLD by MALT1
https://doi.org/10.1016/j.progpolymsci.2015.04.004 Fifteen chemistries for autonomous external self-healing polymers and composites
https://doi.org/10.1039/c4ce01672f Active site engineering in UiO-66 type metal–organic frameworks by intentional creation of defects: a theoretical rationalization
https://doi.org/10.1038/s41591-020-0910-8 Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents
https://doi.org/10.1186/s13046-021-02215-y The CD70-CD27 axis in oncology: the new kids on the block
https://doi.org/10.1186/s13195-021-00939-9 Clinical and analytical comparison of six Simoa assays for plasma P-tau isoforms P-tau181, P-tau217, and P-tau231
https://doi.org/10.1016/j.ijfatigue.2019.01.013 Effect of post-treatments on the fatigue behaviour of 316L stainless steel manufactured by laser powder bed fusion
https://doi.org/10.1007/s11307-008-0133-8 SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression
https://doi.org/10.1371/journal.pone.0017665 Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules
https://doi.org/10.1182/blood-2010-11-317859 Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs
https://doi.org/10.1016/j.pharmthera.2016.06.012 Nanobodies® † †Nanobody is a registered trademark of Ablynx NV. as inhaled biotherapeutics for lung diseases
https://doi.org/10.1186/s13075-015-0651-0 The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis
https://doi.org/10.1002/ajh.25680 Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia
https://doi.org/10.1016/j.ebiom.2022.103836 Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease
https://doi.org/10.3390/met11020204 Cumulative Damage and Life Prediction Models for High-Cycle Fatigue of Metals: A Review
https://doi.org/10.1021/acssuschemeng.8b05072 p-Toluenesulfonic Acid-Based Deep-Eutectic Solvents for Solubilizing Metal Oxides
https://doi.org/10.1126/scitranslmed.aaf8463 Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation
https://doi.org/10.1038/s42003-017-0007-1 Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis
https://doi.org/10.1016/j.compscitech.2015.06.021 Nanofibre bridging as a toughening mechanism in carbon/epoxy composite laminates interleaved with electrospun polyamide nanofibrous veils
https://doi.org/10.1016/j.nbd.2020.105086 How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers, fibrils and oligomers with distinct structures and morphology
https://doi.org/10.1016/j.jhep.2021.08.011 Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model
https://doi.org/10.1111/nph.12436 A novel role of PR2 in abscisic acid (ABA) mediated, pathogen‐induced callose deposition in Arabidopsis thaliana
https://doi.org/10.1126/science.aau2909 Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
https://doi.org/10.1016/j.mrrev.2017.01.001 Ionizing radiation biomarkers in epidemiological studies – An update
https://doi.org/10.1182/blood-2005-03-1153 A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B
The development of nanobodies for therapeutic applications.
https://doi.org/10.1126/scitranslmed.aaa1983 Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo
https://doi.org/10.1186/s13195-017-0276-4 Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer’s disease core biomarkers in Lewy body disorders and Alzheimer’s dementia
https://doi.org/10.1016/j.pmatsci.2018.01.007 Metal recovery by microbial electro-metallurgy
https://doi.org/10.1093/brain/awv199 Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects
https://doi.org/10.1074/jbc.m113.498436 Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growth in Vivo
https://doi.org/10.1039/c4cc03853c Metal–organic frameworks as potential shock absorbers: the case of the highly flexible MIL-53(Al)
https://doi.org/10.1182/blood-2012-04-420943 Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura
https://doi.org/10.1016/j.antiviral.2011.09.002 Nanobodies®: New ammunition to battle viruses
https://doi.org/10.1038/s41467-020-17811-3 Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer
https://doi.org/10.1158/1535-7163.mct-11-0891 Nanobodies Targeting the Hepatocyte Growth Factor: Potential New Drugs for Molecular Cancer Therapy
https://doi.org/10.1258/la.2009.009112 Surface area assessment of the murine intestinal tract as a prerequisite for oral dose translation from mouse to man
https://doi.org/10.1021/acsami.6b02247 Damage-Resistant Composites Using Electrospun Nanofibers: A Multiscale Analysis of the Toughening Mechanisms
https://doi.org/10.1111/jth.13716 Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura
https://doi.org/10.1016/j.ddtec.2010.03.002 Nanobodies – from llamas to therapeutic proteins
https://doi.org/10.1021/acs.chemmater.8b03117 Interfacial Oxidation and Photoluminescence of InP-Based Core/Shell Quantum Dots
https://doi.org/10.1126/scitranslmed.aav7223 A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis
https://doi.org/10.1080/00207543.2010.548409 A method to align a manufacturing execution system with Lean objectives
https://doi.org/10.1016/j.dibe.2020.100022 Detection of corrosion on steel structures using automated image processing
https://doi.org/10.1212/wnl.0000000000012727 Comparing the Clinical Utility and Diagnostic Performance of CSF P-Tau181, P-Tau217, and P-Tau231 Assays
https://doi.org/10.1021/am505621x A Shape-Recovery Polymer Coating for the Corrosion Protection of Metallic Surfaces
https://doi.org/10.1016/s2213-2600(20)30320-9 Nebulised ALX-0171 for respiratory syncytial virus lower respiratory tract infection in hospitalised children: a double-blind, randomised, placebo-controlled, phase 2b trial
https://doi.org/10.1039/c4ta02449d Aliovalent doping of CeO2: DFT study of oxidation state and vacancy effects
https://doi.org/10.1128/jvi.01379-08 Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120
https://doi.org/10.1016/j.compositesb.2018.12.023 Consistent application of periodic boundary conditions in implicit and explicit finite element simulations of damage in composites
https://doi.org/10.1038/s41589-022-01044-0 Detection of cell–cell interactions via photocatalytic cell tagging
https://doi.org/10.3390/antib4030141 Pre-Clinical Intravenous Serum Pharmacokinetics of Albumin Binding and Non-Half-Life Extended Nanobodies®
https://doi.org/10.1038/nm.4390 A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels
https://doi.org/10.1016/j.cemconcomp.2014.12.002 The efficiency of self-healing concrete using alternative manufacturing procedures and more realistic crack patterns
https://doi.org/10.1017/s0031182009990436 Multilocus genotyping of Cryptosporidium and Giardia in non-outbreak related cases of diarrhoea in human patients in Belgium
https://doi.org/10.1039/c5py01069a Model-based design of the polymer microstructure: bridging the gap between polymer chemistry and engineering
https://doi.org/10.1016/j.dyepig.2013.10.048 Substituent effects on absorption spectra of pH indicators: An experimental and computational study of sulfonphthaleine dyes
https://doi.org/10.4161/19420862.2014.975099 Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction
https://doi.org/10.1016/j.nucmedbio.2012.08.008 Targeting breast carcinoma with radioiodinated anti-HER2 Nanobody
https://doi.org/10.3390/polym10050490 Optimisation of the Adhesion of Polypropylene-Based Materials during Extrusion-Based Additive Manufacturing