de Duve Institute

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Title DOI
https://doi.org/10.1038/nature03546 A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
https://doi.org/10.1126/science.1840703 A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma
https://doi.org/10.1016/j.cell.2013.06.037 Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
https://doi.org/10.1542/peds.2014-3673 Vascular Anomalies Classification: Recommendations From the International Society for the Study of Vascular Anomalies
https://doi.org/10.1038/ni.1659 Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset
https://doi.org/10.1038/nrc3670 Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
https://doi.org/10.1002/eji.201970107 Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
https://doi.org/10.1038/nrmicro.2017.26 Oxidative stress, protein damage and repair in bacteria
https://doi.org/10.1038/nm.1924 Chromosome instability is common in human cleavage-stage embryos
https://doi.org/10.1002/art.1780310614 Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
https://doi.org/10.1038/ni1375 Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
https://doi.org/10.1016/s0960-9822(00)00742-9 Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
https://doi.org/10.1128/mmbr.62.4.1315-1352.1998 The Virulence Plasmid ofYersinia, an Antihost Genome
https://doi.org/10.1016/j.devcel.2010.01.011 Organogenesis and Development of the Liver
https://doi.org/10.1146/annurev.micro.54.1.735 Assembly and Function of Type III Secretory Systems
https://doi.org/10.1371/journal.ppat.1000017 IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo
https://doi.org/10.1111/j.1742-4658.2006.05607.x Vitamin C
https://doi.org/10.1086/379793 Capillary Malformation–Arteriovenous Malformation, a New Clinical and Genetic Disorder Caused by RASA1 Mutations
https://doi.org/10.1152/ajpendo.00093.2009 The Randle cycle revisited: a new head for an old hat
https://doi.org/10.1158/0008-5472.can-12-0569 Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
https://doi.org/10.1111/j.1432-1033.1982.tb07039.x A Kinetic Study of Pyrophosphate: Fructose‐6‐Phosphate Phosphotransferase from Potato Tubers
https://doi.org/10.1128/mcb.19.11.7327 DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter
https://doi.org/10.1073/pnas.1113873109 Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
https://doi.org/10.1038/ng.1004 Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
https://doi.org/10.1038/onc.2012.347 JAK/STAT signaling in hematological malignancies
https://doi.org/10.1111/j.1365-2958.1994.tb02191.x Translocation of a hybrid YopE‐adenylate cyclase from Yersinia enterocolitica into HeLa cells
https://doi.org/10.1186/gb-2010-11-1-r3 NetPath: a public resource of curated signal transduction pathways
https://doi.org/10.1113/jphysiol.2006.108506 Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
https://doi.org/10.1038/ng1868 DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis
https://doi.org/10.1038/leu.2016.148 Long-term findings from COMFORT-II, a phase 3 study of ruxolitinib vs best available therapy for myelofibrosis
https://doi.org/10.4049/jimmunol.164.4.1814 Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9
https://doi.org/10.1677/joe-07-0606 Mechanisms of glucocorticoid-induced myopathy
https://doi.org/10.1038/ng.272 Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
https://doi.org/10.1111/j.1748-1716.2009.01970.x AMP‐activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
https://doi.org/10.1073/pnas.92.26.11998 Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach.
https://doi.org/10.18632/oncotarget.2998 Classification of current anticancer immunotherapies
https://doi.org/10.1016/s0960-9822(02)01077-1 Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis
https://doi.org/10.1242/dev.029140 Notch signaling controls liver development by regulating biliary differentiation
https://doi.org/10.1042/bj20040752 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis
https://doi.org/10.1086/303019 Congenital Hereditary Lymphedema Caused by a Mutation That Inactivates VEGFR3 Tyrosine Kinase
https://doi.org/10.1128/jvi.00272-10 Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections
https://doi.org/10.1086/375614 Mutations in the Transcription Factor Gene SOX18 Underlie Recessive and Dominant Forms of Hypotrichosis-Lymphedema-Telangiectasia
https://doi.org/10.1161/01.cir.99.4.578 Glucose for the Heart
https://doi.org/10.1002/humu.20746 Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused byRASA1 mutations
https://doi.org/10.1200/jco.2017.73.9987 Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer
https://doi.org/10.1038/nrc3246 The determinants of tumour immunogenicity
https://doi.org/10.1182/blood-2013-02-485888 Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
https://doi.org/10.1073/pnas.1100552108 IFN-λ determines the intestinal epithelial antiviral host defense
https://doi.org/10.1083/jcb.200205077 Yersiniatype III secretion
https://doi.org/10.4049/jimmunol.167.7.3545 Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types
https://doi.org/10.1038/ncb2031 Identification of the cell lineage at the origin of basal cell carcinoma
https://doi.org/10.3389/fphys.2011.00112 The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise
https://doi.org/10.1038/ncb0905-847 The lysosome turns fifty
https://doi.org/10.1084/jem.20130071 IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
https://doi.org/10.1182/blood-2011-02-292102 New mutations and pathogenesis of myeloproliferative neoplasms
https://doi.org/10.1136/jcp.54.8.577 New insights into the role of cytokines in asthma
https://doi.org/10.3389/fimmu.2015.00588 Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
https://doi.org/10.1089/ars.2010.3114 Structure, Function, and Mechanism of Thioredoxin Proteins
https://doi.org/10.1074/jbc.m205213200 The Stimulation of Glycolysis by Hypoxia in Activated Monocytes Is Mediated by AMP-activated Protein Kinase and Inducible 6-Phosphofructo-2-kinase
https://doi.org/10.1034/j.1600-065x.2002.18806.x Tumor‐specific shared antigenic peptides recognized by human T cells
https://doi.org/10.1074/jbc.m110.152090 Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
https://doi.org/10.1038/nm.1877 Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
https://doi.org/10.1158/2326-6066.cir-14-0137 Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues
https://doi.org/10.1172/jci71614 Genetics of lymphatic anomalies
https://doi.org/10.1073/pnas.170291697 Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor
https://doi.org/10.1007/978-3-540-28785-8 Inborn Metabolic Diseases
https://doi.org/10.1053/j.gastro.2009.02.051 Intrahepatic Bile Ducts Develop According to a New Mode of Tubulogenesis Regulated by the Transcription Factor SOX9
https://doi.org/10.1053/j.gastro.2012.08.024 Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice
https://doi.org/10.1074/jbc.m601225200 MicroRNA-9 Controls the Expression of Granuphilin/Slp4 and the Secretory Response of Insulin-producing Cells
https://doi.org/10.1038/ncb3024 Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development
https://doi.org/10.1001/archderm.144.7.873 Association of Localized Intravascular Coagulopathy With Venous Malformations
https://doi.org/10.1016/j.ajhg.2015.11.011 Somatic Activating PIK3CA Mutations Cause Venous Malformation
https://doi.org/10.1158/0008-5472.can-12-2583 Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
https://doi.org/10.1074/jbc.m506850200 Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491
https://doi.org/10.1038/nn.2555 Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
https://doi.org/10.1086/339492 Mutations in a Novel Factor, Glomulin, Are Responsible for Glomuvenous Malformations (“Glomangiomas”)
https://doi.org/10.4049/jimmunol.179.12.8098 IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis
https://doi.org/10.1182/blood-2015-11-681932 Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
https://doi.org/10.1016/j.bbamcr.2006.08.019 Metabolic functions of glycosomes in trypanosomatids
https://doi.org/10.1016/j.it.2017.05.006 Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape
https://doi.org/10.1084/jem.20072182 Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
https://doi.org/10.1128/mcb.20.12.4445-4454.2000 Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3
https://doi.org/10.1016/j.ccr.2014.03.036 Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
https://doi.org/10.1038/ng.484 Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans
https://doi.org/10.1073/pnas.1432873100 Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules
https://doi.org/10.1258/phleb.2009.009041 Venous malformation: update on aetiopathogenesis, diagnosis and management
https://doi.org/10.1016/s0300-5712(03)00084-8 Long-term evaluation of extensive restorations in permanent teeth
https://doi.org/10.1093/hmg/9.20.2937 Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis
https://doi.org/10.1016/j.stem.2021.04.005 Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
https://doi.org/10.3389/fphar.2019.00820 Formononetin: A Review of Its Anticancer Potentials and Mechanisms
https://doi.org/10.1073/pnas.1012720108 Identifying the cellular origin of squamous skin tumors
https://doi.org/10.1093/hmg/8.2.247 Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease
https://doi.org/10.1074/jbc.m404789200 Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-λ1
https://doi.org/10.1056/nejmoa1206605 Multiple Phenotypes in Phosphoglucomutase 1 Deficiency
https://doi.org/10.1002/humu.22431 RASA1Mutations and Associated Phenotypes in 68 Families with Capillary Malformation-Arteriovenous Malformation
https://doi.org/10.1074/jbc.m209270200 Rab11 Family Interacting Protein 2 Associates with Myosin Vb and Regulates Plasma Membrane Recycling
https://doi.org/10.1016/j.gde.2005.03.004 RASA1: variable phenotype with capillary and arteriovenous malformations
https://doi.org/10.1038/nchembio.1141 Metabolite damage and its repair or pre-emption
https://doi.org/10.1002/eji.200838509 Human natural Treg microRNA signature: Role of microRNA‐31 and microRNA‐21 in FOXP3 expression
https://doi.org/10.4049/jimmunol.1102224 IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice