Mithra Pharmaceuticals (Belgium)

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https://doi.org/10.1016/j.contraception.2020.08.015 Evaluation of the effect of a new oral contraceptive containing estetrol and drospirenone on hemostasis parameters
https://doi.org/10.1016/j.contraception.2021.01.001 Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone
https://doi.org/10.1016/j.contraception.2016.08.018 Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol
https://doi.org/10.1080/17512433.2022.2054413 Profile of estetrol, a promising native estrogen for oral contraception and the relief of climacteric symptoms of menopause
https://doi.org/10.1016/j.contraception.2021.05.002 Estetrol-drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results
https://doi.org/10.1111/1471-0528.16840 Estetrol‐Drospirenone combination oral contraceptive: a clinical study of contraceptive efficacy, bleeding pattern and safety in Europe and Russia
https://doi.org/10.1016/j.chroma.2009.08.051 Critical analysis of several analytical method validation strategies in the framework of the fit for purpose concept
https://doi.org/10.1080/13625187.2022.2093850 A novel estetrol-containing combined oral contraceptive: European expert panel review
https://doi.org/10.1210/clinem/dgac511 Low Thrombin Generation in Users of a Contraceptive Containing Estetrol and Drospirenone
https://doi.org/10.1016/j.contraception.2022.10.004 Tolerability and safety of the estetrol/drospirenone combined oral contraceptive: Pooled analysis of two multicenter, open-label phase 3 trials
https://doi.org/10.1007/s40268-023-00419-5 Estetrol: From Preclinical to Clinical Pharmacology and Advances in the Understanding of the Molecular Mechanism of Action
https://doi.org/10.1080/13697137.2022.2139599 Impact of estetrol (E4) on hemostasis, metabolism and bone turnover in postmenopausal women
https://doi.org/10.1016/j.xagr.2023.100266 The benefits of estetrol addition to drospirenone for contraception
https://doi.org/10.1177/10760296241286514 Impact of Estetrol Combined with Drospirenone on Blood Coagulation and Fibrinolysis in Patients with Endometriosis: A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study
https://doi.org/10.1016/j.fertnstert.2024.07.011 Efficacy and safety of the combination of estetrol 15 mg/drospirenone 3 mg in a cyclic regimen for the treatment of endometriosis-associated pain and objective gynecological findings: a multicenter, placebo-controlled, double-blind, randomized study
https://doi.org/10.1097/gme.0000000000001561 A multicenter, randomized study to select the minimum effective dose of estetrol (E4) in postmenopausal women (E4Relief): part 1. Vasomotor symptoms and overall safety
https://doi.org/10.1093/infdis/jiaa300 Immunogenicity of the Adjuvanted Recombinant Zoster Vaccine: Persistence and Anamnestic Response to Additional Doses Administered 10 Years After Primary Vaccination
https://doi.org/10.1159/000029816 Effect of Avène Spring Water on the Activation of Rat Mast Cell by Substance P or Antigen
https://doi.org/10.1158/1535-7163.mct-21-0406 Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506
https://doi.org/10.1007/s40264-021-01076-w Safety Profile of the Adjuvanted Recombinant Zoster Vaccine in Immunocompromised Populations: An Overview of Six Trials
https://doi.org/10.1016/j.talanta.2009.03.009 A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture
https://doi.org/10.3390/jcm11154634 Bleeding Patterns of Oral Contraceptives with a Cyclic Dosing Regimen: An Overview
https://doi.org/10.1016/j.contraception.2021.03.003 Effects of an oral contraceptive containing estetrol and drospirenone on ovarian function
https://doi.org/10.3390/cancers13102486 Estetrol Combined to Progestogen for Menopause or Contraception Indication Is Neutral on Breast Cancer
https://doi.org/10.1007/978-3-030-11355-1_12 Unique Vascular Benefits of Estetrol, a Native Fetal Estrogen with Specific Actions in Tissues (NEST)
https://doi.org/10.1016/j.contraception.2022.07.010 Pooled analysis of two phase 3 trials evaluating the effects of a novel combined oral contraceptive containing estetrol/drospirenone on bleeding patterns in healthy women
https://doi.org/10.1016/j.contraception.2022.07.009 Pooled efficacy results of estetrol/drospirenone combined oral contraception phase 3 trials
https://doi.org/10.1097/gme.0000000000002167 A multicenter, randomized, placebo-controlled study to select the minimum effective dose of estetrol in postmenopausal participants (E4Relief): part 2—vaginal cytology, genitourinary syndrome of menopause, and health-related quality of life
https://doi.org/10.1016/j.aquatox.2023.106505 Estetrol has a lower impact than 17α-ethinylestradiol on the reproductive capacity of zebrafish (Danio rerio)
https://doi.org/10.1016/j.thromres.2022.09.007 Estetrol is not a SERM but a NEST and has a specific safety profile on coagulation
https://doi.org/10.1039/d3re00051f Metal-free synthesis of an estetrol key intermediate under intensified continuous flow conditions
https://doi.org/10.1016/j.rpth.2023.100155 Hormonal therapies and venous thrombosis: considerations for prevention and management—a reappraisal
https://doi.org/10.1080/13697137.2023.2292066 Low thrombin generation in postmenopausal women using estetrol
https://doi.org/10.1523/eneuro.0271-23.2024 Role of Membrane Estrogen Receptor Alpha on the Positive Feedback of Estrogens on Kisspeptin and GnRH Neurons
https://doi.org/10.1016/j.aquatox.2024.106941 Evaluating the toxicity of estetrol, 17α-ethinylestradiol, and their combination with drospirenone on zebrafish larvae: A behavioural and proteomic study
https://doi.org/10.3390/jcm12123928 Estetrol Is Safe and Well Tolerated during Treatment of Hospitalized Men and Women with Moderate COVID-19 in a Randomized, Double-Blind Study
https://doi.org/10.1016/j.ejogrb.2023.08.350 Prediction of venous thromboembolism risk associated with combined oral contraceptives: an exploratory model
https://doi.org/10.1210/jendso/bvab048.1495 The Effect of Estetrol/Drospirenone on Ovarian Function Is Similar to a Well-Established Combined Oral Contraceptive: Results From a Phase 2 Study
https://doi.org/10.1016/j.bvth.2025.100100 Procoagulant off-target effect of the direct oral anticoagulant reversal agent andexanet alfa
https://doi.org/10.1002/bit.20158 Perfusion cultures of human tumor cells: a scalable production platform for oncolytic adenoviral vectors
https://doi.org/10.1016/j.jpba.2011.08.040 Comparison of the quantitative performances and measurement uncertainty estimates obtained during method validation versus routine applications of a novel hydrophilic interaction chromatography method for the determination of cidofovir in human plasma
https://doi.org/10.1164/rccm.202108-1892oc Bacillus Calmette-Guérin Skin Reaction Predicts Enhanced Mycobacteria-Specific T-Cell Responses in Infants: A Post Hoc Analysis of a Randomized Controlled Trial
https://doi.org/10.1016/j.mtcomm.2020.101208 Synthesis of medical grade PLLA, PDLLA, and PLGA by a reactive extrusion polymerization
https://doi.org/10.1039/c8ay01264d Comparison of poly(styrene-divinylbenzene)-based monolithic and bead-based methodologies used in NANOFLOW LCMS for proteomic studies
https://doi.org/10.1210/jendso/bvad114.1574 FRI378 Estetrol Prolongs Anagen In Healthy Female Scalp Hair Follicles By Positively Modulating Dermal Papilla Functions And Generation Of Progenitor Stem Cells Ex Vivo
https://doi.org/10.3390/ijms24119718 Comparison of Estetrol Exposure between Women and Mice to Model Preclinical Experiments and Anticipate Human Treatment
https://doi.org/10.1111/jne.13341 Role of membrane estrogen receptor alpha ( ERα ) in the rapid regulation of male sexual behavior
https://doi.org/10.1016/j.maturitas.2019.04.122 Estetrol (E4), the next generation hormone therapy (HT) for menopausal symptoms: phase 2b clinical trial results
https://doi.org/10.1016/s0378-4347(99)00018-3 Determination of clindamycin in human plasma by liquid chromatography–electrospray tandem mass spectrometry: application to the bioequivalence study of clindamycin
https://doi.org/10.1111/j.1472-8206.1998.tb00970.x In vitro effects of Uriage spring water on the apoptosis of human eosinophils
https://doi.org/10.1016/j.maturitas.2021.08.013 Estetrol (E4) is a native fetal estrogen that does not modify coagulation markers in postmenopausal women and maintains sensitivity to activated protein C (APC)
https://doi.org/10.5957/jsr.1968.12.3.163 Pressure Stability of Orthotropic Prolate Spheroids
https://doi.org/10.1016/j.jsxm.2022.05.099 Estetrol, a Natural Estrogen with Selective Tissue activity (NEST)
https://doi.org/10.1016/j.envint.2024.108702 Estetrol/drospirenone versus 17α-ethinylestradiol/drospirenone: An extended one generation test to evaluate the endocrine disruption potential on zebrafish (Danio rerio)
https://doi.org/10.1080/13625187.2024.2359117 Effects of E4/DRSP on self-reported physical and emotional premenstrual and menstrual symptoms: data from the phase 3 clinical trial in Europe and Russia
https://doi.org/10.1002/food.19670110107 Die intestinal‐enzymatische Spaltung von Galakto‐Oligosacchariden im Darm von Tier und Mensch mit besonderer Berücksichtigung von Lactobacillus bifidus 3. Mitt. Carbohydratische Aktivität ausgewählter Mikroorganismen der Darmflora
https://doi.org/10.1210/js.2019-sun-lb001 SUN-LB001 Estetrol (E4) Is a Unique Estrogen with Selective Actions in Tissues Which Are Distinctly Different from the Actions of SERMs
https://doi.org/10.1093/jsxmed/qdad068.054 (059) Estetrol(E4) is a Unique Estrogen With Selective Actions in Tissues Which Are Distinctly Different From the Actions of SERMs
https://doi.org/10.1071/aseg2009ab073 Greenfield nickel sulphide exploration using airborne and ground EM techniques in the eastern arunta region, NT.
https://doi.org/10.1016/j.maturitas.2021.08.019 Effects of estetrol on vaginal cytology, genitourinary syndrome of menopause and health-related wuality of life: results from the E4Relief Phase 2b Study
https://doi.org/10.5114/pm.2023.128815 Response to paper by Binkowska et al. Risk of venous thromboembolism during the use of oral estrogen-progestogenhormone therapies in light of most recent research findings. Commentary: Oestradiol is not the holy grail in the quest forthe ideal oestrogen therapy
https://doi.org/10.1002/food.19670110303 Nahrungsfette und Lipidstoffwechsel 2. Mitt. Die Wirkung der Nahrungsfette auf die Fettsäurezusammensetzung der Leberlipide
https://doi.org/10.1080/00268976200100631 On the effect of next nearest-neighbour ions on the crystal field splitting of transition metal ions in crystals
https://doi.org/10.1002/food.19870310821 Zur Kenntnis der Schwefelverbindungen in Raps‐ (Brassica napus) Varietäten und Verarbeitungsprodukten 4. Mitt. Präparative Isolation von Glucosinolaten und Glucosinolatgemischen
https://doi.org/10.1101/2023.03.22.533736 Role of membrane estrogen receptor alpha on the positive feedback of estrogens on LH secretion
https://doi.org/10.1002/food.19690130604 Über das Verhalten von Pflanzenschutz‐ und Schädlingsbekämpfungsmittel‐Rückständen bei der Be‐ und Verarbeitung von Lebensmitteln 2. Mitt. Das Verhalten der chlororganischen Insektizide bei der industriellen Milchpulverherstellung
Liposome Encapsulating Estetrol For The Treatment Of Ischemia Diseases In Prematures Babies
https://doi.org/10.1016/j.purol.2018.07.054 Effets fonctionnels de l’estétrol (e4) sur le bas appareil urinaire de la souris ovariectomisée
https://doi.org/10.1210/jendso/bvab048.1482 An Oral Contraceptive Containing Estetrol 15 MG and Drospirenone 3 MG Has Limited Effects on Endocrine and Metabolic Parameters
https://doi.org/10.1016/j.jid.2023.03.1402 1386 Estetrol prolongs anagen in healthy female scalp hair follicles by positively modulating dermal papilla functions and generation of progenitor stem cells ex vivo
https://doi.org/10.1093/jsxmed/qdad061.064 (068) Low Drug-Drug interaction risk of Estetrol (E4), a Promising New Estrogen for the Treatment of Menopausal Symptoms
https://doi.org/10.1093/jsxmed/qdad068.013 (013) Estetrol Combined with Drospirenone: An Investigational Oral Contraceptive With A Selective Impact on Endocrine Parameters
https://doi.org/10.1093/bjd/ljae105.025 P03 Anti-ageing effects of oestetrol on the skin: protection from cellular senescence and restoration of dermal architecture
https://doi.org/10.1016/j.jaad.2024.07.815 52790 Estetrol (E4) prolongs anagen ex vivo: Does E4 have the potential as novel strategy to treat female pattern hair loss?
https://doi.org/10.1115/1.4070464 Dynamic Modeling and Experimental Insights in a 10 kWe Micro Gas Turbine Prototype: Experimental Validation and Testing
https://doi.org/10.1055/s-0045-1814507 A novel fibrin-targeted urokinase fusion protein enhances thrombolytic efficacy with reduced bleeding risk
GT2025-153032