Publications in OpenAlex of which a co-author is affiliated to this organization
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| Title | DOI |
|---|---|
| https://doi.org/10.1186/s12931-021-01791-z | Global incidence and prevalence of idiopathic pulmonary fibrosis |
| https://doi.org/10.1016/s0140-6736(16)32537-5 | Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib (the FITZROY study): results from a phase 2, double-blind, randomised, placebo-controlled trial |
| https://doi.org/10.1016/s0140-6736(21)00666-8 | Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial |
| https://doi.org/10.4161/cc.8.12.8606 | Rapamycin decelerates cellular senescence |
| https://doi.org/10.1038/s41586-019-1444-4 | Global spatial risk assessment of sharks under the footprint of fisheries |
| https://doi.org/10.4161/cc.10.24.18486 | Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice |
| https://doi.org/10.1111/j.1523-1739.2005.00228.x | Feral Goat Eradications on Islands |
| https://doi.org/10.1001/jama.2019.9055 | Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy |
| https://doi.org/10.1603/0013-8746(2006)099[0121:aitaif]2.0.co;2 | Alien Insects: Threats and Implications for Conservation of Galápagos Islands |
| https://doi.org/10.1016/s0140-6736(18)32463-2 | Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial |
| https://doi.org/10.1136/annrheumdis-2020-219214 | Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial |
| https://doi.org/10.1016/s2213-2600(18)30181-4 | Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial |
| https://doi.org/10.1136/annrheumdis-2016-210104 | Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1) |
| https://doi.org/10.4049/jimmunol.1201348 | Preclinical Characterization of GLPG0634, a Selective Inhibitor of JAK1, for the Treatment of Inflammatory Diseases |
| https://doi.org/10.1136/annrheumdis-2016-210105 | Filgotinib (GLPG0634/GS-6034), an oral selective JAK1 inhibitor, is effective as monotherapy in patients with active rheumatoid arthritis: results from a randomised, dose-finding study (DARWIN 2) |
| https://doi.org/10.1021/jm401507s | Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor |
| https://doi.org/10.1016/s0140-6736(18)32483-8 | Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active psoriatic arthritis (EQUATOR): results from a randomised, placebo-controlled, phase 2 trial |
| https://doi.org/10.4161/cc.8.24.10215 | Pseudo-DNA damage response in senescent cells |
| https://doi.org/10.1126/science.1160649 | The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons |
| https://doi.org/10.1083/jcb.200406060 | Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway |
| https://doi.org/10.1136/annrheumdis-2020-219213 | Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial |
| https://doi.org/10.1021/acs.jmedchem.7b00032 | Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- a ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis |
| https://doi.org/10.1007/s40262-015-0240-z | Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose Selection |
| https://doi.org/10.4161/cc.9.21.13584 | Weak p53 permits senescence during cell cycle arrest |
| https://doi.org/10.1021/jm501262q | Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 |
| https://doi.org/10.1021/acs.jcim.3c00013 | Enhancing Hit Discovery in Virtual Screening through Absolute Protein–Ligand Binding Free-Energy Calculations |
| https://doi.org/10.1016/j.jid.2018.01.036 | Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis |
| https://doi.org/10.1128/aac.01175-13 | A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ |
| https://doi.org/10.1371/journal.pone.0023834 | The Hedgehog Receptor Patched Is Involved in Cholesterol Transport |
| https://doi.org/10.1038/s41586-023-05790-6 | Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates |
| https://doi.org/10.1021/jm5012885 | Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic |
| https://doi.org/10.1016/j.cell.2020.06.007 | The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome |
| https://doi.org/10.1001/jama.2023.5355 | Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis |
| https://doi.org/10.1136/bmjresp-2019-000422 | Rationale, design and objectives of two phase III, randomised, placebo-controlled studies of GLPG1690, a novel autotaxin inhibitor, in idiopathic pulmonary fibrosis (ISABELA 1 and 2) |
| https://doi.org/10.1007/s00227-014-2393-y | Inter-island movements of scalloped hammerhead sharks (Sphyrna lewini) and seasonal connectivity in a marine protected area of the eastern tropical Pacific |
| https://doi.org/10.4161/cc.8.12.8809 | Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence |
| https://doi.org/10.1179/bac.2012.33.1.004 | Zinc white: a review of zinc oxide pigment properties and implications for stability in oil-based paintings |
| https://doi.org/10.1007/s10530-004-3574-2 | Can We Infer Island Introduction and Naturalization Rates from Inventory Data? Evidence from Introduced Plants in Galapagos |
| https://doi.org/10.1126/sciadv.abo1754 | Diving into the vertical dimension of elasmobranch movement ecology |
| https://doi.org/10.3390/jcm9041140 | The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis |
| https://doi.org/10.1002/art.40186 | Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK‐1 Inhibitor, After Short‐Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials |
| https://doi.org/10.1007/s00227-013-2375-5 | Seasonal changes in movements and habitat preferences of the scalloped hammerhead shark (Sphyrna lewini) while refuging near an oceanic island |
| https://doi.org/10.1038/s41541-020-00261-9 | Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate |
| https://doi.org/10.1080/13602365.2012.724881 | Henri Lefebvre on Space: Architecture, Urban Research, and the Production of Theory |
| https://doi.org/10.1126/scitranslmed.adh0908 | Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis |
| https://doi.org/10.1111/eva.12682 | Population genomics through time provides insights into the consequences of decline and rapid demographic recovery through head‐starting in a Galapagos giant tortoise |
| https://doi.org/10.5985/emcr.20210009 | Plastic additives and legacy persistent organic pollutants in the preen gland oil of seabirds sampled across the globe |
| https://doi.org/10.1371/journal.pone.0138779 | Description of a New Galapagos Giant Tortoise Species (Chelonoidis; Testudines: Testudinidae) from Cerro Fatal on Santa Cruz Island |
| https://doi.org/10.1016/0006-3207(89)90019-0 | The rare plants of the Galápagos Islands and their conservation |
| https://doi.org/10.1002/ieam.4661 | Multiple anthropogenic stressors in the Galápagos Islands' complex social–ecological system: Interactions of marine pollution, fishing pressure, and climate change with management recommendations |
| https://doi.org/10.1002/ajhb.23344 | Water, food, and the dual burden of disease in Galápagos, Ecuador |
| https://doi.org/10.1186/s13075-018-1541-z | Effect of filgotinib, a selective JAK 1 inhibitor, with and without methotrexate in patients with rheumatoid arthritis: patient-reported outcomes |
| https://doi.org/10.1111/bcp.12900 | Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects |
| https://doi.org/10.1016/j.envpol.2022.120011 | Microplastic distribution and composition on two Galápagos island beaches, Ecuador: Verifying the use of citizen science derived data in long-term monitoring |
| https://doi.org/10.1021/acs.jmedchem.0c02008 | Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis |
| https://doi.org/10.1080/03007995.2021.1971185 | Open Pharma recommendations for plain language summaries of peer-reviewed medical journal publications |
| https://doi.org/10.1007/s40262-022-01129-y | Filgotinib: A Clinical Pharmacology Review |
| https://doi.org/10.1111/resp.14154 | Idiopathic pulmonary fibrosis: Physician and patient perspectives on the pathway to care from symptom recognition to diagnosis and disease burden |
| https://doi.org/10.1126/science.adf5167 | The NIH-led research response to COVID-19 |
| https://doi.org/10.1021/acs.jmedchem.0c00272 | Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial |
| https://doi.org/10.1016/j.joca.2023.04.001 | Evaluation of S201086/GLPG1972, an ADAMTS-5 inhibitor, for the treatment of knee osteoarthritis in ROCCELLA: a phase 2 randomized clinical trial |
| https://doi.org/10.1614/0890-037x(2004)018[1194:tcoahi]2.0.co;2 | The Control of a Highly Invasive Tree Cinchona pubescens in Galapagos1 |
| https://doi.org/10.1201/9781003138846-4 | Predicting Responses of Geo-ecological Carbonate Reef Systems to Climate Change: A Conceptual Model and Review |
| https://doi.org/10.1126/scitranslmed.abj3289 | IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases |
| https://doi.org/10.4161/cbt.4.4.1702 | Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin |
| https://doi.org/10.5751/ace-01596-150119 | Roadkill of birds in Galapagos Islands: a growing need for solutions |
| https://doi.org/10.1007/s12325-022-02168-4 | MANTA and MANTA-RAy: Rationale and Design of Trials Evaluating Effects of Filgotinib on Semen Parameters in Patients with Inflammatory Diseases |
| https://doi.org/10.1183/13993003.01794-2022 | GLPG1205 for idiopathic pulmonary fibrosis: a phase 2 randomised placebo-controlled trial |
| https://doi.org/10.1136/ard-2023-224017 | Effects of filgotinib on semen parameters and sex hormones in male patients with inflammatory diseases: results from the phase 2, randomised, double-blind, placebo-controlled MANTA and MANTA-RAy studies |
| https://doi.org/10.1126/science.1114395 | Living Laboratory in Peril |
| https://doi.org/10.1093/rheumatology/keab543 | Impact of filgotinib on sacroiliac joint magnetic resonance imaging structural lesions at 12 weeks in patients with active ankylosing spondylitis (TORTUGA trial) |
| https://doi.org/10.1016/j.chembiol.2022.12.006 | Autotaxin facilitates selective LPA receptor signaling |
| https://doi.org/10.1387/ausart.21490 | A critique of contemporary artificial intelligence art: Who is Edmond de Belamy? |
| https://doi.org/10.1038/s42255-023-00919-3 | Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells |
| https://doi.org/10.1159/000506833 | Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages |
| https://doi.org/10.1080/00219266.2016.1175758 | In Galápagos … and Uncomfortable with Evolution |
| https://doi.org/10.1021/acs.jmedchem.1c00138 | Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis |
| https://doi.org/10.1136/annrheumdis-2022-eular.1646 | POS0680 PHYSICIANS' REASONS FOR PRESCRIBING JANUS KINASE INHIBITORS (JAKi) IN PATIENTS WITH RHEUMATOID ARTHRITIS (RA), AND ASSOCIATED ALIGNMENT BETWEEN PHYSICIANS AND PATIENTS IN A REAL-WORLD CLINICAL SETTING |
| https://doi.org/10.1038/497306a | Invasive species: The 18-km2 rat trap |
| https://doi.org/10.1007/s10641-021-01204-6 | Studies of the movement ecology of sharks justify the existence and expansion of marine protected areas in the Eastern Pacific Ocean |
| https://doi.org/10.1126/sciadv.adf6601 | Genomic evidence for homoploid hybrid speciation in a marine mammal apex predator |
| https://doi.org/10.1093/ecco-jcc/jjae003 | Efficacy and Safety of Filgotinib for the Treatment of Perianal Fistulising Crohn’s Disease [DIVERGENCE 2]: A Phase 2, Randomised, Placebo-controlled Trial |
| https://doi.org/10.1021/acs.jmedchem.3c02246 | Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases |
| https://doi.org/10.1021/acs.jmedchem.1c01066 | Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases |
| https://doi.org/10.1021/acs.jmedchem.3c01428 | Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312 |
| https://doi.org/10.1093/ecco-jcc/jjad018 | Filgotinib Improved Health-Related Quality of Life and Led to Comprehensive Disease Control in Individuals with Ulcerative Colitis: Data from the SELECTION Trial |
| https://doi.org/10.1038/s41558-024-02129-5 | Climate-driven global redistribution of an ocean giant predicts increased threat from shipping |
| https://doi.org/10.1080/19331681.2022.2150737 | The Impact of Political Memes: a Longitudinal Field Experiment |
| https://doi.org/10.1136/ard-2024-225759 | Integrated safety analysis of filgotinib in patients with moderate-to-severe rheumatoid arthritis over a treatment duration of up to 8.3 years |
| https://doi.org/10.1093/ibd/izae119 | Residual Disease Burden Among European Patients With Inflammatory Bowel Disease: A Real-World Survey |
| https://doi.org/10.1111/apt.18158 | Long‐term safety and efficacy of filgotinib for the treatment of moderately to severely active ulcerative colitis: Interim analysis from up to 4 years of follow‐up in the SELECTION open‐label long‐term extension study |
| https://doi.org/10.1002/cpt.2689 | Ziritaxestat Drug–Drug Interaction with Oral Contraceptives: Role of SULT1E1 Inhibition |
| https://doi.org/10.1002/ohn.1225 | Comparative Analysis of Information Quality in Pediatric Otorhinolaryngology: Clinicians, Residents, and Large Language Models |
| https://doi.org/10.1016/j.envpol.2023.121936 | High aluminum content in bone of marine mammals and its relation with source levels and origin |
| https://doi.org/10.1016/j.marpol.2024.106448 | Shortfalls in the protection of Important Shark and Ray Areas undermine shark conservation efforts in the Central and South American Pacific |
| https://doi.org/10.1016/j.omtn.2025.102549 | Removal of dsRNA byproducts using affinity chromatography |
| https://doi.org/10.1016/j.atmosres.2025.107918 | Operational satellite cloud products need local adjustment – The Galapagos case of ecoclimatic cloud zonation |
| https://doi.org/10.1080/10408398.2024.2431207 | Resilient foods for preventing global famine: a review of food supply interventions for global catastrophic food shocks including nuclear winter and infrastructure collapse |
| https://doi.org/10.1136/rmdopen-2024-004476 | Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study |
| https://doi.org/10.1097/pep.0000000000001129 | Clinical Factors Related to Abnormal General Movements Trajectories: Development of a Multicriteria Index |