Publications in OpenAlex of which a co-author is affiliated to this organization
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| Title | DOI |
|---|---|
| https://doi.org/10.1038/s41573-025-01308-z | Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety |
| https://doi.org/10.1523/jneurosci.3987-04.2004 | Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide |
| https://doi.org/10.4161/cc.8.12.8810 | At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence |
| https://doi.org/10.1074/jbc.m306957200 | Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin |
| https://doi.org/10.1111/j.1523-1739.2006.00423.x | Predicting Pathogen Introduction: West Nile Virus Spread to Galápagos |
| https://doi.org/10.2174/1871520611313050008 | Type II Kinase Inhibitors: An Opportunity in Cancer for Rational Design |
| https://doi.org/10.1111/j.1439-0310.1978.tb01843.x | On the Biology of Tropidurus delanonis, Baur (Iguanidae) |
| https://doi.org/10.4161/cc.10.10.15789 | The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1α |
| https://doi.org/10.1002/art.24470 | The α7 nicotinic acetylcholine receptor on fibroblast‐like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation |
| https://doi.org/10.1186/ar3119 | A multiparameter approach to monitor disease activity in collagen-induced arthritis |
| https://doi.org/10.1016/b978-0-444-62652-3.00004-1 | Advances in the Discovery of Selective JAK Inhibitors |
| https://doi.org/10.1653/0015-4040(2005)088[0159:eotlfa]2.0.co;2 | ERADICATION OF THE LITTLE FIRE ANT, WASMANNIA AUROPUNCTATA (HYMENOPTERA: FORMICIDAE), FROM MARCHENA ISLAND, GALÁPAGOS: ON THE EDGE OF SUCCESS? |
| https://doi.org/10.1085/jgp.201912360 | Identifying the molecular target sites for CFTR potentiators GLPG1837 and VX-770 |
| https://doi.org/10.1016/s0166-0934(01)00257-9 | Rapid determination of adenoviral vector titers by quantitative real-time PCR |
| https://doi.org/10.4161/cbt.5.1.2289 | The role of relaxin in endometrial cancer |
| https://doi.org/10.1021/js9701061 | Mechanical Properties of Compacts and Particles that Control Tableting Success |
| https://doi.org/10.1007/s10637-015-0320-9 | A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies |
| https://doi.org/10.1085/jgp.201711886 | A common mechanism for CFTR potentiators |
| https://doi.org/10.1002/art.38973 | Effect of Certolizumab Pegol Over Ninety‐Six Weeks in Patients With Axial Spondyloarthritis: Results from a Phase III Randomized Trial |
| https://doi.org/10.1007/s13402-011-0058-0 | BMP-7 inhibits TGF-β-induced invasion of breast cancer cells through inhibition of integrin β3 expression |
| https://doi.org/10.1017/s0376892903001188 | The Galápagos sea cucumber fishery: management improves as stocks decline |
| https://doi.org/10.1021/acs.jmedchem.7b00647 | Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors |
| https://doi.org/10.18268/bsgm2005v57n1a6 | La falla Chacalapa en el sur de Oaxaca |
| https://doi.org/10.1021/jo400989q | Strategy for the Synthesis of Pyridazine Heterocycles and Their Derivatives |
| https://doi.org/10.1021/acs.jmedchem.7b01288 | Discovery ofN-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent |
| https://doi.org/10.1021/acs.jcim.7b00642 | Shedding Light on Important Waters for Drug Design: Simulations versus Grid-Based Methods |
| https://doi.org/10.2174/1872312810666151223103353 | Clinical Confirmation that the Selective JAK1 Inhibitor Filgotinib (GLPG0634) has a Low Liability for Drug-drug Interactions |
| https://doi.org/10.4161/cc.8.22.10121 | Cellular quiescence caused by the Mdm2 inhibitor Nutlin-3A |
| https://doi.org/10.1016/j.jcf.2019.04.014 | CFTR activity is enhanced by the novel corrector GLPG2222, given with and without ivacaftor in two randomized trials |
| https://doi.org/10.3390/cancers11030359 | RETRACTED: The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models |
| https://doi.org/10.1007/s10592-005-8704-6 | Population Genetic Structure and Conservation of the Galápagos Petrel (Pterodroma phaeopygia) |
| https://doi.org/10.1038/onc.2011.594 | Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish |
| https://doi.org/10.1038/s41598-017-18159-3 | Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 |
| https://doi.org/10.1111/jdv.16126 | IL‐17C amplifies epithelial inflammation in human psoriasis and atopic eczema |
| https://doi.org/10.1136/vr.c6520 | Sterilisation of hybrid Galapagos tortoises ( Geochelone nigra ) for island restoration. Part 1: endoscopic oophorectomy of females under ketamine‐medetomidine anaesthesia |
| https://doi.org/10.1021/ml400095m | Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections |
| https://doi.org/10.1890/13-0169.1 | Oceanographic and climatic variation drive top‐down/bottom‐up coupling in the Galápagos intertidal meta‐ecosystem |
| https://doi.org/10.1002/cbic.200600189 | REPLACE: A Strategy for Iterative Design of Cyclin‐Binding Groove Inhibitors |
| https://doi.org/10.1097/ncn.0b013e3181f9db79 | The Use of Bedside Electronic Medical Record to Improve Quality of Care in Nursing Facilities |
| https://doi.org/10.1097/ncn.0b013e3181f69838 | Improving Nurse Care Coordination With Technology |
| https://doi.org/10.1002/jcph.1424 | Safety, Pharmacokinetics, and Pharmacodynamics of the Autotaxin Inhibitor GLPG1690 in Healthy Subjects: Phase 1 Randomized Trials |
| https://doi.org/10.3389/fphar.2018.01221 | Identification and Characterization of Novel CFTR Potentiators |
| https://doi.org/10.3899/jrheum.201183 | Safety and Efficacy of Filgotinib: Up to 4-year Results From an Open-label Extension Study of Phase II Rheumatoid Arthritis Programs |
| https://doi.org/10.4103/0972-4923.101835 | Understanding Science in Conservation: A Q Method Approach on the Galápagos Islands |
| https://doi.org/10.3389/fphar.2019.00514 | Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators |
| https://doi.org/10.3390/ijerph16050682 | Socio-Ecological Factors Associated with Dengue Risk and Aedes aegypti Presence in the Galápagos Islands, Ecuador |
| https://doi.org/10.1016/j.jcf.2018.05.011 | Physiological and pharmacological characterization of the N1303K mutant CFTR |
| https://doi.org/10.1016/j.chemosphere.2021.129821 | Heavy metal contents, mobility and origin in agricultural topsoils of the Galápagos Islands |
| https://doi.org/10.1111/j.1469-1795.2012.00567.x | Applying the tools of ecological immunology to conservation: a test case in the |
| https://doi.org/10.1098/rspa.2008.0278 | Theory of quantum arrival and spatial wave function collapse on the appearance of particle |
| https://doi.org/10.1186/s13045-017-0530-z | Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells |
| https://doi.org/10.1039/c8nj01544a | Metal–azole fungistatic drug complexes as anti-Sporothrixspp. agents |
| https://doi.org/10.1111/jcpe.12271 | Non‐surgical and supportive periodontal therapy: predictors of compliance |
| https://doi.org/10.1186/1471-2148-9-297 | Progressive colonization and restricted gene flow shape island-dependent population structure in Galápagos marine iguanas (Amblyrhynchus cristatus) |
| https://doi.org/10.1016/j.yrtph.2017.08.008 | A consortium-driven framework to guide the implementation of ICH M7 Option 4 control strategies |
| https://doi.org/10.1071/sr18331 | Agriculture changes soil properties on the Galápagos Islands – two case studies |
| https://doi.org/10.1038/s41388-020-01396-8 | USP13 controls the stability of Aurora B impacting progression through the cell cycle |
| https://doi.org/10.1016/bs.pmch.2018.01.001 | Recent Progress in the Discovery and Development of Small-Molecule Modulators of CFTR |
| https://doi.org/10.1007/s10822-021-00405-6 | Multitask machine learning models for predicting lipophilicity (logP) in the SAMPL7 challenge |
| https://doi.org/10.1016/bs.pmch.2020.02.001 | Discovery and development of ASK1 inhibitors |
| https://doi.org/10.1002/art.42477 | A |
| https://doi.org/10.1124/jpet.119.261800 | Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222 |
| https://doi.org/10.1039/d0mo00189a | A novel multi-omics-based highly accurate prediction of symptoms, comorbid conditions, and possible long-term complications of COVID-19 |
| https://doi.org/10.1183/13993003.01581-2021 | Evaluation of a novel CFTR potentiator in COPD ferrets with acquired CFTR dysfunction |
| https://doi.org/10.14309/ajg.0000000000001979 | Rapid and Sustained Symptom Relief in Patients With Ulcerative Colitis Treated With Filgotinib: Data From the Phase 2b/3 SELECTION Trial |
| https://doi.org/10.1016/j.jcf.2019.05.006 | GLPG1837, a CFTR potentiator, in p.Gly551Asp (G551D)-CF patients: An open-label, single-arm, phase 2a study (SAPHIRA1) |
| https://doi.org/10.1136/annrheumdis-2019-eular.8676 | LB0001 EFFICACY AND SAFETY OF FILGOTINIB FOR PATIENTS WITH RHEUMATOID ARTHRITIS WITH INADEQUATE RESPONSE TO METHOTREXATE: FINCH1 PRIMARY OUTCOME RESULTS |
| https://doi.org/10.3389/fmed.2021.711194 | Patient Reported Experiences and Delays During the Diagnostic Pathway for Pulmonary Fibrosis: A Multinational European Survey |
| https://doi.org/10.1186/s12931-022-01976-0 | Epidemiology, healthcare utilization, and related costs among patients with IPF: results from a German claims database analysis |
| https://doi.org/10.1093/rheumatology/kez408 | Effect of filgotinib on health-related quality of life in active psoriatic arthritis: a randomized phase 2 trial (EQUATOR) |
| https://doi.org/10.1111/cobi.13319 | Genetically informed captive breeding of hybrids of an extinct species of Galapagos tortoise |
| https://doi.org/10.1016/j.joca.2021.08.012 | Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5 |
| https://doi.org/10.1021/ol501529z | Synthesis of Fused 3-Aminoazepinones via Trapping of a New Class of Cyclic Seven-Membered Allenamides with Furan |
| https://doi.org/10.1093/ecco-jcc/jjad022 | Mercaptopurine for the Treatment of Ulcerative Colitis: A Randomized Placebo-Controlled Trial |
| https://doi.org/10.1136/annrheumdis-2012-202221 | Oral administration of GLPG0259, an inhibitor of MAPKAPK5, a new target for the treatment of rheumatoid arthritis: a phase II, randomised, double-blind, placebo-controlled, multicentre trial |
| https://doi.org/10.1093/rheumatology/keab758 | Filgotinib decreases both vertebral body and posterolateral spine inflammation in ankylosing spondylitis: results from the TORTUGA trial |
| https://doi.org/10.1002/cpdd.1042 | Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip |
| https://doi.org/10.1093/ecco-jcc/jjac058 | The Impact of Vedolizumab and Ustekinumab on Articular Extra-Intestinal Manifestations in Inflammatory Bowel Disease Patients: A Real-Life Multicentre Cohort Study |
| https://doi.org/10.1002/ejoc.201402983 | Synthesis of Furans through Silver‐Catalyzed Propargyl–Claisen Rearrangement Followed by Cyclocondensation |
| https://doi.org/10.1021/acs.jmedchem.0c01796 | Discovery of GLPG2451, a Novel Once Daily Potentiator for the Treatment of Cystic Fibrosis |
| https://doi.org/10.1016/j.marenvres.2022.105696 | The impact of climate change on the distribution of Sphyrna lewini in the tropical eastern Pacific |
| https://doi.org/10.1136/rmdopen-2022-002658 | Treat-to-target in rheumatoid arthritis: a real-world study of the application and impact of treat-to-target within the wider context of patient management, patient centricity and advanced therapy use in Europe |
| https://doi.org/10.37135/ee.004.07.09 | Preeclampsia - eclampsia diagnóstico y tratamiento |
| https://doi.org/10.3390/ijms22105361 | A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy |
| https://doi.org/10.1038/s41467-022-31280-w | The genomic basis of the plant island syndrome in Darwin’s giant daisies |
| https://doi.org/10.1007/s10393-019-01456-w | Water Security in the Galápagos: Socioecological Determinants and Health Implications |
| https://doi.org/10.1165/rcmb.2019-0291oc | Novel Correctors and Potentiators Enhance Translational Readthrough in CFTR Nonsense Mutations |
| https://doi.org/10.1002/ece3.7807 | Cooperation and opportunism in Galapagos sea lion hunting for shoaling fish |
| https://doi.org/10.1093/ecco-jcc/jjab232.017 | OP18 Efficacy and safety of filgotinib for the treatment of perianal fistulizing Crohn’s Disease: Results from the phase 2 DIVERGENCE 2 study |
| https://doi.org/10.1093/ibd/izab330 | Inadequate Response, Treatment Patterns, Health Care Utilization, and Associated Costs in Patients With Ulcerative Colitis: Retrospective Cohort Study Based on German Claims Data |
| https://doi.org/10.1111/apt.17674 | Integrated safety analysis of filgotinib for ulcerative colitis: Results from SELECTION and SELECTIONLTE |
| https://doi.org/10.4155/ppa.14.23 | Toward Selective TYK2 Inhibitors As Therapeutic Agents for the Treatment of Inflammatory Diseases |
| https://doi.org/10.1111/j.1526-100x.2012.00891.x | Population Response of Giant Galápagos Tortoises to Feral Goat Removal |
| https://doi.org/10.1136/annrheumdis-2016-eular.3862 | THU0173 Filgotinib (GLPG0634), An Oral Jak1 Selective Inhibitor Is Effective as Monotherapy in Patients with Active Rheumatoid Arthritis: Results from A 24-Week Phase 2B Dose Ranging Study |
| https://doi.org/10.1093/mr/roab030 | Efficacy and safety of filgotinib in combination with methotrexate in Japanese patients with active rheumatoid arthritis who have an inadequate response to methotrexate: Subpopulation analyses of 24-week data of a global phase 3 study (FINCH 1) |
| https://doi.org/10.55563/clinexprheumatol/vuc5py | Performance of the 2017 EULAR/ACR Classification Criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a scoping review |
| https://doi.org/10.1136/annrheumdis-2019-eular.8678 | LB0003 EFFICACY AND SAFETY OF FILGOTINIB FOR PATIENTS WITH RHEUMATOID ARTHRITIS NAïVE TO METHOTREXATE THERAPY: FINCH3 PRIMARY OUTCOME RESULTS |
| https://doi.org/10.5217/ir.2021.00143 | Efficacy and safety of filgotinib as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a post-hoc analysis of the phase 2b/3 SELECTION trial |
| https://doi.org/10.1136/annrheumdis-2016-eular.1954 | OP0224 Filgotinib (GLPG0634), An Oral Jak1 Selective Inhibitor Is Effective in Combination with Methotrexate in Patients with Active Rheumatoid Arthritis: Results from A 24-Week Phase 2B Dose Ranging Study |
| https://doi.org/10.1111/rec.13476 | Introduction of giant tortoises as a replacement “ecosystem engineer” to facilitate restoration of Santa Fe Island, Galapagos |