Roche (Belgium)

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Title DOI
https://doi.org/10.1016/0092-8674(95)90151-5 Identification and expression cloning of a leptin receptor, OB-R
https://doi.org/10.1111/j.1365-2222.1994.tb00920.x Attenuation of allergic airway inflammation in IL‐4 deficient mice
https://doi.org/10.1074/jbc.272.7.4065 Leptin Receptor (OB-R) Signaling
https://doi.org/10.1038/s41523-020-0156-0 Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
https://doi.org/10.1038/s41523-020-0154-2 Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
https://doi.org/10.1016/j.apenergy.2018.09.008 Performances and modelling of a circular moving bed thermochemical reactor for seasonal storage
https://doi.org/10.1016/0092-8674(91)90040-6 A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF
https://doi.org/10.1074/jbc.272.29.18304 Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
https://doi.org/10.1097/00007691-200310000-00011 Twelve-Month Evaluation of the Clinical Pharmacokinetics of Total and Free Mycophenolic Acid and Its Glucuronide Metabolites in Renal Allograft Recipients on Low Dose Tacrolimus in Combination with Mycophenolate Mofetil
https://doi.org/10.1111/j.1365-2222.1993.tb00317.x The potential role of tumour necrosis factor a in asthma
https://doi.org/10.1084/jem.172.3.683 Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.
https://doi.org/10.1016/s0014-5793(97)00192-0 A human leptin mutant induces weight gain in normal mice
https://doi.org/10.1016/j.ejca.2006.11.019 Phosphorylated HER-2 tyrosine kinase and Her-2/neu gene amplification as predictive factors of response to trastuzumab in patients with HER-2 overexpressing metastatic breast cancer (MBC)
https://doi.org/10.1007/s10549-020-05604-7 Safety and tolerability of subcutaneous trastuzumab at home administration, results of the phase IIIb open-label BELIS study in HER2-positive early breast cancer
https://doi.org/10.1159/000491750 Clinical and Economic Impact of Adopting Noninvasive Prenatal Testing as a Primary Screening Method for Fetal Aneuploidies in the General Pregnancy Population
https://doi.org/10.1016/j.ejogrb.2017.01.010 The impact on women’s health and the cervical cancer screening budget of primary HPV screening with dual-stain cytology triage in Belgium
https://doi.org/10.1016/j.est.2018.08.015 Performance characterization of salt-in-silica composite materials for seasonal energy storage design
https://doi.org/10.1016/j.preghy.2021.06.012 Cost-utility of a first-trimester screening strategy versus the standard of care for nulliparous women to prevent pre-term pre-eclampsia in Belgium
https://doi.org/10.1038/s41523-020-0155-1 Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
https://doi.org/10.1093/jaenfo/jnz037 Common ownership: an EU perspective
https://doi.org/10.1084/jem.189.1.207-a Leptin Is an Endogenous Protective Protein against the Toxicity Exerted by Tumor Necrosis Factor
https://doi.org/10.1038/361266a0 Human TNF mutants with selective activity on the p55 receptor
https://doi.org/10.1002/ijc.2910500220 Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells
https://doi.org/10.1073/pnas.93.11.5668 OB protein binds specifically to the choroid plexus of mice and rats.
https://doi.org/10.1073/pnas.92.11.5194 Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist.
https://doi.org/10.1200/jco.2009.27.15_suppl.4532 Rash as a marker for the efficacy of gemcitabine plus erlotinib-based therapy in pancreatic cancer: Results from the AViTA Study
https://doi.org/10.1016/j.corsci.2018.04.020 Severe corrosion of steel and copper by strontium bromide in thermochemical heat storage reactors
https://doi.org/10.1016/j.est.2018.04.027 Humidity dependence of transport properties of composite materials used for thermochemical heat storage and thermal transformer appliances
https://doi.org/10.1002/jmv.22049 Efficacy of interferon‐based antiviral therapy in patients with chronic hepatitis C infected with genotype 5: A meta‐analysis of two large prospective clinical trials
https://doi.org/10.1016/j.preghy.2021.08.113 Enhancing the value of the sFlt-1/PlGF ratio for the prediction of preeclampsia: Cost analysis from the Belgian healthcare payers’ perspective
https://doi.org/10.1158/0008-5472.sabcs11-ot1-02-04 OT1-02-04: Adjuvant Pertuzumab and Herceptin IN IniTial TherapY of Breast Cancer: APHINITY (BIG 4–11/BO25126/TOC4939g).
https://doi.org/10.1073/pnas.89.15.7041 Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.
https://doi.org/10.1159/000236947 Importance of lnterleukin-4 and lnterleukin-12 in Allergen-Induced Airway Changes in Mice
https://doi.org/10.2337/diacare.25.2.303 A Health Economic Model to Assess the Long-Term Effects and Cost-Effectiveness of Orlistat in Obese Type 2 Diabetic Patients
https://doi.org/10.1002/j.1460-2075.1995.tb07345.x Detailed analysis of the IL-5-IL-5R alpha interaction: characterization of crucial residues on the ligand and the receptor.
https://doi.org/10.1111/j.1432-1033.1994.00635.x Covalent modification of the interleukin‐5 receptor by isothiazolones leads to inhibition of the binding of interleukin‐5
https://doi.org/10.1016/j.ejca.2008.09.036 Managing cancer-related anaemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: Initial evidence from the RESPOND study
https://doi.org/10.1016/j.indmarman.2011.11.023 Customer value creation: A journey in the search of excellence
https://doi.org/10.1371/journal.pone.0031639 Statin Use and the Presence of Microalbuminuria. Results from the ERICABEL Trial: A Non-Interventional Epidemiological Cohort Study
https://doi.org/10.1016/j.lungcan.2009.09.003 Comparison of four antibodies for immunohistochemical evaluation of epidermal growth factor receptor expression in non-small cell lung cancer
https://doi.org/10.1007/978-3-0348-7276-8_3 Structure/Function Analysis of Human Interleukin 5 and its Receptor
https://doi.org/10.1016/j.egypro.2017.09.522 Energy Performances of Open Sorption Reactor with Ultra-Low Grade Heat Upgrading for Thermochemical Energy Storage Applications
https://doi.org/10.1136/ijgc-2021-003190 Prospective non-interventional BELOVA/BGOG-ov16 study on safety of frontline bevacizumab in elderly patients with FIGO stage IV ovarian cancer: a study of the Belgian and Luxembourg Gynaecological Oncology Group
https://doi.org/10.1093/protein/7.1.5 Structure-activity studies of human tumour necrosis factors
https://doi.org/10.1165/ajrcmb.17.6.2820 Role of IFN-γ in the Inhibition of the Allergic Airway Inflammation Caused by IL-12
https://doi.org/10.1200/jco.2007.25.18_suppl.2005 Randomized phase II trial of erlotinib (E) versus temozolomide (TMZ) or BCNU in recurrent glioblastoma multiforme (GBM): EORTC 26034
https://doi.org/10.1111/j.1432-1033.1994.tb18678.x Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor
https://doi.org/10.1002/eji.1830250710 Characterization of critical residues in the cytoplasmic domain of the human interleukin‐5 receptor α chain required for growth signal transduction
https://doi.org/10.1002/jlb.57.6.813 Interleukin-5 and its receptor: a drug target for eosinophilia associated with chronic allergic disease
Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene.
https://doi.org/10.1007/978-0-585-31728-1_13 The Role of Interleukin 5 in the Production and Function of Eosinophils
https://doi.org/10.1111/j.1476-5381.1994.tb17111.x Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage
https://doi.org/10.1007/s00520-009-0718-z Promoting evidence-based management of anemia in cancer patients: concurrent and discriminant validity of RESPOND, a web-based clinical guidance system based on the EORTC guidelines for supportive care in cancer
https://doi.org/10.1200/jco.2004.22.14_suppl.733 Effect of 1-year intravenous ibandronate treatment on time to serum creatinine increase in patients with skeletal metastases from breast cancer
https://doi.org/10.14309/ctg.0000000000000005 Risk of Upper Gastrointestinal Bleeding and Gastroduodenal Ulcers in Persons With Schizophrenia: A Danish Cohort Study
https://doi.org/10.1158/1538-7445.sabcs16-p4-21-17 Abstract P4-21-17: BELIS: Safety and tolerability of at home administration of trastuzumab (Herceptin®) subcutaneous for the treatment of patients with HER2-positive early breast cancer
https://doi.org/10.1371/journal.pone.0293544 The budget impact of procalcitonin-guided antibiotic stewardship compared to standard of care for patients with suspected sepsis admitted to the intensive care unit in Belgium
https://doi.org/10.1016/s0021-9258(18)53290-7 Recombinant soluble human interleukin-5 (hIL-5) receptor molecules. Cross-linking and stoichiometry of binding to IL-5.
https://doi.org/10.1007/978-3-642-85232-9_18 Interleukin-5 Receptor α Subunit Gene Regulation in Human Eosinophil Development: Identification of a Unique Cis-Element that acts lie an Enhacer in Regulating Activity of the IL-5Rα Promoter
https://doi.org/10.1111/ecc.12146 Survival outcomes in patients with advanced non-small cell lung cancer treated with erlotinib: expanded access programme data from Belgium (the TRUST study)
https://doi.org/10.1002/j.1460-2075.1991.tb07747.x Molecular basis of a high affinity murine interleukin-5 receptor.
https://doi.org/10.1084/jem.189.1.207 Leptin Is an Endogenous Protective Protein against the Toxicity Exerted by Tumor Necrosis Factor
https://doi.org/10.1089/dna.1.1989.8.491 Expression of Human and Murine Interleukin-5 in Eukaryotic Systems
https://doi.org/10.1007/bf02245838 Moclobemide versus fluoxetine for a major depressive episode
https://doi.org/10.1111/j.1365-2249.1993.tb06506.x IL-5 in post-traumatic eosinophilic pleural effusion
https://doi.org/10.1006/prep.1997.0836 Efficient Secretion of Biologically Active Recombinant OB Protein (Leptin) inEscherichia coli,Purification from the Periplasm and Characterization
https://doi.org/10.1097/00002826-199417001-00007 Moclobemide Versus Fluoxetine for Major Depressive Episodes
https://doi.org/10.1006/prep.1993.1031 High-Level Expression, Purification, and Renaturation of Recombinant Murine Interleukin-2 from Escherichia coli
https://doi.org/10.1097/00003643-199705000-00005 Intravenous administration of tenoxicam 40 mg for post-operative analgesia: A double-blind, placebo-controlled multicentre study
https://doi.org/10.1016/j.critrevonc.2007.05.002 Promoting evidence-based management of anemia in cancer patients: Background, development, and scientific validation of RESPOND, a web-based clinical guidance system based on the EORTC guidelines
https://doi.org/10.1200/jco.2005.23.16_suppl.6123 A time-in-motion study of oral ibandronate versus iv zoledronic acid for treatment of metastatic bone disease in breast cancer patients
https://doi.org/10.1093/annonc/mdw200.30 PD-030 Prospective non-interventional study to collect data on the use of bevacizumab and conventional chemotherapy for the treatment of previously untreated metastatic colorectal cancer in patient's ≥70 years
https://doi.org/10.1183/13993003.congress-2016.oa4572 PROOF: A prospective observational registry to describe the disease course and outcomes of idiopathic pulmonary fibrosis patients in a real-world clinical setting in Belgium and Luxembourg: Exposure in the interim report of 175 IPF patients
https://doi.org/10.1200/jco.2007.25.18_suppl.19633 RESPOND - Raising awareness of anemia in oncology centers through computer algorithm driven guidelines: Assessment of intraclass correlation metrics for the accuracy of algorithmic definitions
https://doi.org/10.1016/j.jval.2017.08.1021 Cost-Effectiveness Analysis Of Primary HPV Screening With Dual-Stain Cytology Triage In The Cervical Cancer Screening Program Of Belgium
https://doi.org/10.4049/jimmunol.147.10.3413 Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies. Relationship to the murine IL-3 receptor
https://doi.org/10.1016/0014-5793(89)81560-1 Conserved residues of tumour necrosis factor and lymphotoxin constitute the framework of the trimeric structure
https://doi.org/10.1016/0014-5793(93)80295-6 Expression, purification and crystallization of fully active, glycosylated human interleukin‐5
https://doi.org/10.1159/000236318 Effect of Theophylline on Endotoxin and Tumor Necrosis Factor Induced Airway Changes in an in vivo Animal Model
https://doi.org/10.1016/s0011-393x(05)80650-2 The influence of cilazapril on anticoagulation in hypertensive patients treated with coumarins
https://doi.org/10.1097/00002826-199202001-00817 MOCLOBEMIDE VS. FLUOXETINE FOR A MAJOR DEPRESSIVE EPISODE
https://doi.org/10.1016/0006-291x(90)90711-u Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes
https://doi.org/10.1016/0924-977x(93)90106-v Moclobemide versus fluoxetine for a major depressive episode
https://doi.org/10.1007/978-94-009-6342-9_7 Powering of a Solar Heated Swimming Pool
https://doi.org/10.1108/15285810710759515 Implementation of the Transparency Directive changes shareholder notification requirements across Europe
https://doi.org/10.1016/0924-977x(93)90136-a Do new antidepressants influence body weight? Comparing moclobemide to fluoxetine
https://doi.org/10.1016/0011-393x(95)85089-9 Cilazapril in arterial hypertension: effect on the trough-to-peak ratio and on ambulatory blood pressure recorded in an office setting
https://doi.org/10.1007/s00769-004-0884-0 Implementation of an integrated glucose POCT system
https://doi.org/10.1093/annonc/mdv233.251 P-254 A multicentre, non-interventional, post-authorization study to observe in daily clinical practice the treatment duration of patients treated with bevacizumab in 1st line mCRC in Belgium
https://doi.org/10.1182/blood.v110.11.1737.1737 Rituximab Therapy for Autoimmune Hemolytic Anemia and Immune Thrombocytopenia: A Belgian Registry.
https://doi.org/10.1200/jco.2007.25.18_suppl.19676 Promoting evidence-based management of anemia in cancer patients: Background and scientific validation of RESPOND, a web-based clinical decision support system
https://doi.org/10.1158/0008-5472.sabcs11-p1-12-01 P1-12-01: Pregnancy during and Following Adjuvant Trastuzumab in Patients with HER2−Positive Breast Cancer: An Analysis from the HERA Trial (BIG 01-01).
https://doi.org/10.1016/0304-3959(88)90188-1 re, Pain measurement in reflex sympathetic dystrophy syndrome, Pain, 32 (1988) 27–34
https://doi.org/10.1016/b978-0-12-388170-0.50013-3 The IL-5 Receptor on Human Eosinophils
https://doi.org/10.5962/bhl.title.120107 Zoologie des Alpes-Maritimes ou Catalogue des animaux observés dans le département /
https://doi.org/10.1200/jco.2005.23.16_suppl.8060 Oral ibandronate preceded by an intravenous (i.v.) ibandronate loading dose in patients with breast cancer and bone metastases or multiple myeloma: phase III results
https://doi.org/10.1042/bst027a055 Sequence analysis and characterisation of the rat orthologue of TNFα converting enzyme (TACE)
https://doi.org/10.1093/annonc/mdx261.350 A multicenter non-interventional study exploring the impact of sarcopenia on the outcomes of colorectal cancer patients treated with chemotherapy plus bevacizumab – avawatchers
https://doi.org/10.1016/j.jval.2018.09.259 PCN176 - A COST-EFFECTIVENESS ANALYSIS OF ATEZOLIZUMAB VERSUS DOCETAXEL FOR PREVIOUSLY TREATED LOCALLY ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER IN BELGIUM
https://doi.org/10.1093/annonc/mdw370.94 AVAPLUS: Impact of geriatric assessment on first-line treatment duration (TD) and progression free survival (PFS) in mCRC patients ≥ 70 years