Anticancer Fund

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Title DOI
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.
https://doi.org/10.1172/jci20032 Gene expression profiling predicts clinical outcome of prostate cancer
https://doi.org/10.1200/jco.2007.13.3934 Individual Fluorouracil Dose Adjustment Based on Pharmacokinetic Follow-Up Compared With Conventional Dosage: Results of a Multicenter Randomized Trial of Patients With Metastatic Colorectal Cancer
https://doi.org/10.1038/nrclinonc.2015.169 Drug repurposing in oncology—patient and health systems opportunities
https://doi.org/10.3332/ecancer.2017.781 Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents
https://doi.org/10.3332/ecancer.2014.485 Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent
https://doi.org/10.1016/s1470-2045(00)00292-8 Marine organisms as a source of new anticancer agents
https://doi.org/10.1186/s13023-019-1075-8 Information needs of physicians regarding the diagnosis of rare diseases: a questionnaire-based study in Belgium
https://doi.org/10.1186/s40425-018-0381-3 White paper on microbial anti-cancer therapy and prevention
https://doi.org/10.3332/ecancer.2015.521 Repurposing Drugs in Oncology (ReDO)—itraconazole as an anti-cancer agent
https://doi.org/10.3332/ecancer.2018.886 ReDO_DB: the repurposing drugs in oncology database
https://doi.org/10.3332/ecancer.2016.610 Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
https://doi.org/10.4161/cc.8.6.7891 Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain ofSalmonella typhymurium
https://doi.org/10.3332/ecancer.2016.680 Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent
https://doi.org/10.4161/cc.9.22.13744 Vessel destruction by tumor-targetingSalmonella typhimuriumA1-R is enhanced by high tumor vascularity
https://doi.org/10.4161/cc.10.5.14969 The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla
https://doi.org/10.1007/s00216-015-8484-x Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers
https://doi.org/10.1038/s41598-017-18924-4 Vitamin E inhibits the UVAI induction of “light” and “dark” cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes
https://doi.org/10.3332/ecancer.2015.513 Repurposing Drugs in Oncology (ReDO)—clarithromycin as an anti-cancer agent
https://doi.org/10.1016/j.trecan.2017.06.007 Repurposing Drugs in Oncology: Next Steps
https://doi.org/10.3389/fphar.2019.01664 On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients
https://doi.org/10.3389/fphar.2018.00637 “Hard” Drug Repurposing for Precision Oncology: The Missing Link?
https://doi.org/10.1093/noajnl/vdab075 A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
https://doi.org/10.1016/j.semcancer.2020.01.008 Repurposing drugs in oncology: From candidate selection to clinical adoption
https://doi.org/10.1186/s12885-019-5676-3 PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer
https://doi.org/10.3389/fphar.2021.627574 An Open Access Database of Licensed Cancer Drugs
https://doi.org/10.3389/fnut.2018.00138 A Phase 2 Study to Assess the Immunomodulatory Capacity of a Lecithin-based Delivery System of Curcumin in Endometrial Cancer
https://doi.org/10.1186/s13063-021-05273-x Exploring new uses for existing drugs: innovative mechanisms to fund independent clinical research
https://doi.org/10.1007/s00262-022-03253-x Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study
https://doi.org/10.3390/cancers16050998 Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)
https://doi.org/10.3389/fonc.2021.688755 Repurposing Infectious Diseases Vaccines Against Cancer
https://doi.org/10.1016/j.jcms.2024.12.009 Evaluation of a context-aware chatbot using retrieval-augmented generation for answering clinical questions on medication-related osteonecrosis of the jaw
https://doi.org/10.1038/s41563-025-02188-9 Biorhythm-mimicking growth hormone patch
https://doi.org/10.1002/path.6017 Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage
https://doi.org/10.1080/0284186x.2021.1953136 Use of non-cancer drugs and survival among patients with pancreatic adenocarcinoma: a nationwide registry-based study in Norway
https://doi.org/10.3389/fonc.2019.01408 Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue—Going Beyond Apoptosis Induction
https://doi.org/10.1038/s41467-024-53398-9 Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
https://doi.org/10.1186/s12943-025-02365-z Targeting metastasis in paediatric bone sarcomas
https://doi.org/10.1016/s1470-2045(24)00736-8 New models for the development of and access to CAR T-cell therapies for children and adolescents with cancer: an ACCELERATE multistakeholder analysis
https://doi.org/10.1016/j.ygyno.2024.10.020 Associations of the gut microbiome with outcomes in cervical and endometrial cancer patients treated with pembrolizumab: Insights from the phase II PRIMMO trial
https://doi.org/10.1021/acs.jmedchem.5c01025 Antibacterial Metallacarborane-Peptide Hybrids Target the Membrane Potential in a Nonlytic Mode and Are Resistant to Proteolysis
https://doi.org/10.1016/j.eclinm.2025.103203 Genetic predisposition in sarcomas: clinical implications and management
https://doi.org/10.1021/acs.jmedchem.5c01594 Design, Synthesis and Biological Evaluation of 7-(1-Methyl-1H-indole-3-yl)-5H-pyrrolo[2,3-b]pyrazine Derivatives as Novel Covalent pan-FGFR Inhibitors to Overcome Clinical Resistance
https://doi.org/10.1158/0008-5472.can-06-0217 Targeting the Lymphotoxin-β Receptor with Agonist Antibodies as a Potential Cancer Therapy
Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate.
https://doi.org/10.1097/00000421-200210000-00015 Phase II Trial of Cisplatin Plus Decitabine, a New DNA Hypomethylating Agent, in Patients With Advanced Squamous Cell Carcinoma of the Cervix
https://doi.org/10.1158/1078-0432.ccr-03-0068 Pharmacokinetics, Methionine Depletion, and Antigenicity of Recombinant Methioninase in Primates
https://doi.org/10.1111/j.1939-1676.2010.0559.x Ultrasonography Criteria for Differentiating ACTH Dependency from ACTH Independency in 47 Dogs with Hyperadrenocorticism and Equivocal Adrenal Asymmetry
https://doi.org/10.1007/s00253-005-0038-2 High-level expression and bulk crystallization of recombinant l-methionine γ-lyase, an anticancer agent
https://doi.org/10.1016/j.otsr.2018.01.010 Accuracy of patient-specific guided implantation of the glenoid component in reversed shoulder arthroplasty
https://doi.org/10.1111/j.1346-8138.2011.01413.x Nestin‐positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury
https://doi.org/10.1039/c6qo00526h [3 + 2] Cycloaddition of aza-oxyallyl cations with aldehydes
https://doi.org/10.3332/ecancer.2015.568 Repurposing Drugs in Oncology (ReDO)—nitroglycerin as an anti-cancer agent
https://doi.org/10.1111/cen.13369 Circulating thyroid cancer biomarkers: Current limitations and future prospects
https://doi.org/10.3332/ecancer.2018.824 Repurposing drugs in oncology (ReDO)—selective PDE5 inhibitors as
https://doi.org/10.2217/fon.14.244 Repurposing drugs in your medicine cabinet: untapped opportunities for cancer therapy?
https://doi.org/10.1093/carcin/bgs097 Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
https://doi.org/10.2147/ott.s42245 Docetaxel-carboplatin in combination with erlotinib and/or bevacizumab in patients with non-small cell lung cancer
https://doi.org/10.1016/j.ejca.2020.04.038 Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents
https://doi.org/10.1111/j.1346-8138.2008.00578.x Multipotent nestin‐expressing hair follicle stem cells
https://doi.org/10.1136/bmj.k2701 New uses for old drugs
https://doi.org/10.1038/s43018-020-0030-x Challenges and opportunities for cancer clinical trials in low- and middle-income countries
https://doi.org/10.1038/nrclinonc.2017.69 Scientific advice — is drug repurposing missing a trick?
https://doi.org/10.2217/fon-2019-0233 Journal Retractions in Oncology: A Bibliometric Study
https://doi.org/10.1016/j.ejca.2021.10.016 Paediatric Strategy Forum for medicinal product development of chimeric antigen receptor T-cells in children and adolescents with cancer
https://doi.org/10.4161/cc.10.12.15895 Watching stem cells in the skin of living mice noninvasively
https://doi.org/10.3332/ecancer.2015.ed50 The wisdom of crowds and the repurposing of artesunate as an anticancer drug
https://doi.org/10.1016/s1470-2045(18)30076-7 Cancer groundshot: going global before going to the moon
https://doi.org/10.1517/14712590902845610 RANKL inhibition: Clinical implications for the management of patients with multiple myeloma and solid tumors with bone metastases
https://doi.org/10.1007/s00018-010-0265-2 The corticotropin releasing factor system in cancer: expression and pathophysiological implications
https://doi.org/10.1111/j.1939-1676.2011.0773.x Use of Computed Tomography Adrenal Gland Measurement for Differentiating ACTH Dependence from ACTH Independence in 64 Dogs with Hyperadenocorticism
https://doi.org/10.4149/neo_2019_190110n34 Evidence of β-blockers drug repurposing for the treatment of triple negative breast cancer: A systematic review
https://doi.org/10.1159/000085617 The Irinotecan/5-Fluorouracil Combination Induces Apoptosis and Enhances Manganese Superoxide Dismutase Activity in HT-29 Human Colon Carcinoma Cells
https://doi.org/10.1159/000076387 Pituitary Metastasis of Follicular Thyroid Carcinoma
https://doi.org/10.3332/ecancer.2018.ed82 Propranolol and breast cancer—a work in progress
https://doi.org/10.1080/2162402x.2015.1049802 Cryoablation and Meriva have strong therapeutic effect on triple-negative breast cancer
https://doi.org/10.1136/jitc-2020-001250 Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
https://doi.org/10.3389/fphar.2021.790952 A Database of Drug Repurposing Clinical Trials in Oncology
https://doi.org/10.4161/15384101.2014.991604 Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging
https://doi.org/10.1016/j.ejca.2020.08.014 Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children
https://doi.org/10.1200/go.20.00591 Trends in International Cancer Research Investment 2006-2018
https://doi.org/10.1046/j.1365-2141.1999.01196.x Course of the International Normalized Ratio in response to oral vitamin K1 in patients overanticoagulated with phenprocoumon
https://doi.org/10.1371/journal.pone.0225748 Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial
https://doi.org/10.1111/php.13551 Perspectives on Cyclobutane Pyrimidine Dimers—Rise of the Dark Dimers
https://doi.org/10.1016/j.jcpo.2022.100375 Cancer literacy – Informing patients and implementing shared decision making
https://doi.org/10.1016/j.ejca.2022.06.008 Paediatric Strategy Forum for medicinal product development of multi-targeted kinase inhibitors in bone sarcomas
https://doi.org/10.3389/fmed.2021.817663 Repurposing of Medicines in the EU: Launch of a Pilot Framework
https://doi.org/10.1016/j.ejca.2017.07.021 Orphan Drug Regulation: A missed opportunity for children and adolescents with cancer
https://doi.org/10.3389/fphar.2022.960701 How to balance valuable innovation with affordable access to medicines in Belgium?
https://doi.org/10.3332/ecancer.2016.689 Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6–8 May 2016, Mumbai
https://doi.org/10.1200/go.22.00233 European Cancer Organisation's Inequalities Network: Putting Cancer Inequalities on the European Policy Map
https://doi.org/10.1186/s13613-021-00925-2 High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study
https://doi.org/10.1200/jco.21.01916 When Innovation and Commercialization Collide: A Patient Advocate View in Neuroblastoma
https://doi.org/10.1016/j.ejca.2023.112950 Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration
https://doi.org/10.3389/fphar.2021.599598 A Randomized Phase II Trial Comparing the Efficacy and Safety of Pioglitazone, Clarithromycin and Metronomic Low-Dose Chemotherapy with Single-Agent Nivolumab Therapy in Patients with Advanced Non-small Cell Lung Cancer Treated in Second or Further Line (ModuLung)
https://doi.org/10.21873/cdp.10008 Stereotactic Body Radiation Therapy Boost in Patients With Cervical Cancer Ineligible for Brachytherapy
https://doi.org/10.1158/1078-0432.ccr-24-0101 Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement
https://doi.org/10.3389/fphar.2019.00287 A Computational Model of Tumor Growth and Anakoinosis
https://doi.org/10.1016/j.annonc.2023.05.006 Patient-centered, self-funding dose optimization trials as a route to reduce toxicity, lower cost, and improve access to cancer therapy
https://doi.org/10.1016/j.ejmech.2022.114904 2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization