Center for Beta Cell Therapy in Diabetes

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Title DOI
https://doi.org/10.1056/nejmoa043980 Insulin Needs after CD3-Antibody Therapy in New-Onset Type 1 Diabetes
https://doi.org/10.1016/j.cell.2007.12.015 β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
https://doi.org/10.1016/j.cell.2009.05.035 The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
https://doi.org/10.1016/j.devcel.2009.11.003 Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth
https://doi.org/10.1007/s00125-012-2571-8 Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase
https://doi.org/10.1038/ng.2007.62 Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
https://doi.org/10.1016/j.cmet.2006.10.001 GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
https://doi.org/10.2337/db07-1614 miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells
https://doi.org/10.1007/s00125-009-1644-9 Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
https://doi.org/10.2337/diabetes.53.5.1326 Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors
https://doi.org/10.1136/gut.50.4.571 Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension
https://doi.org/10.1002/hep.510290232 Class Vi Intermediate Filament Protein Nestin Is Induced During Activation of Rat Hepatic Stellate Cells
https://doi.org/10.1007/s00125-011-2109-5 Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function
https://doi.org/10.1073/pnas.0801059105 Interleukin-6 regulates pancreatic α-cell mass expansion
https://doi.org/10.2337/diabetes.51.3.686 Gastrin Stimulates β-Cell Neogenesis and Increases Islet Mass From Transdifferentiated but Not From Normal Exocrine Pancreas Tissue
https://doi.org/10.1210/jc.2018-00728 Programmed Cell Death-1 Inhibitor–Induced Type 1 Diabetes Mellitus
https://doi.org/10.1007/s00125-013-2906-0 Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
https://doi.org/10.4161/isl.3.4.15728 Insulitis in human type 1 diabetes
https://doi.org/10.1016/s0014-5793(02)03110-1 Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells
https://doi.org/10.2337/db09-1486 Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
https://doi.org/10.2337/db07-0416 Screening for Insulitis in Adult Autoantibody-Positive Organ Donors
https://doi.org/10.1371/journal.pone.0002435 Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
https://doi.org/10.1016/j.diabres.2014.08.010 Air pollution and risk of type 2 diabetes mellitus: A systematic review and meta-analysis
https://doi.org/10.1210/en.2009-0708 β-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes in db/db Mice
https://doi.org/10.1073/pnas.0608141103 Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft
https://doi.org/10.1016/j.jadohealth.2008.04.005 Identity Development, Coping, and Adjustment in Emerging Adults With a Chronic Illness: The Sample Case of Type 1 Diabetes
https://doi.org/10.1016/j.cmet.2013.11.007 Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells
https://doi.org/10.1053/j.gastro.2011.04.050 Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas
https://doi.org/10.1074/jbc.m411869200 Glucose Suppresses Superoxide Generation in Metabolically Responsive Pancreatic β Cells
https://doi.org/10.2337/diacare.25.5.840 The Incidence of Type 1 Diabetes in the Age Group 0–39 Years Has Not Increased in Antwerp (Belgium) Between 1989 and 2000
https://doi.org/10.1016/j.bcp.2004.04.003 Metformin-induced stimulation of AMP-activated protein kinase in β-cells impairs their glucose responsiveness and can lead to apoptosis
https://doi.org/10.1373/clinchem.2019.304196 Islet Autoantibody Standardization Program 2018 Workshop: Interlaboratory Comparison of Glutamic Acid Decarboxylase Autoantibody Assay Performance
https://doi.org/10.2337/dc10-2268 Contribution of Antibodies Against IA-2β and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age
https://doi.org/10.2337/db09-1698 β-Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support
https://doi.org/10.1111/pedi.13105 Glucose management for exercise using continuous glucose monitoring ( CGM ) and intermittently scanned CGM ( isCGM ) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes ( EASD ) and of the International Society for Pediatric and Adolescent Diabetes ( ISPAD ) endorsed by JDRF and supported by the American Diabetes Association ( ADA )
https://doi.org/10.1016/j.stemcr.2018.01.040 Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control
https://doi.org/10.1111/j.1600-6143.2008.02479.x Allograft-Specific Cytokine Profiles Associate with Clinical Outcome After Islet Cell Transplantation
https://doi.org/10.1074/jbc.m700083200 Specificity in Beta Cell Expression of l-3-Hydroxyacyl-CoA Dehydrogenase, Short Chain, and Potential Role in Down-regulating Insulin Release
https://doi.org/10.1016/j.jaut.2011.05.012 Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers
https://doi.org/10.1517/14712598.2012.684875 Recent developments in transposon-mediated gene therapy
https://doi.org/10.1038/s41467-020-19485-3 Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence
https://doi.org/10.1111/dme.13264 Ketosis‐prone atypical diabetes in Cameroonian people with hyperglycaemic crisis: frequency, clinical and metabolic phenotypes
https://doi.org/10.1002/sctm.19-0043 Cell Mass Increase Associated with Formation of Glucose-Controlling β-Cell Mass in Device-Encapsulated Implants of hiPS-Derived Pancreatic Endoderm
https://doi.org/10.1007/s001250050960 Extra-insular beta cells associated with ductules are frequent in adult human pancreas
https://doi.org/10.1007/s00418-002-0412-4 Nestin expression in pancreatic stellate cells and angiogenic endothelial cells
https://doi.org/10.1007/s001250051468 Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
https://doi.org/10.1002/hep.510230634 Comparison of Glial Fibrillary Acidic Protein and Desmin Staining in Normal and Ccl4–Induced Fibrotic Rat Livers
https://doi.org/10.1677/jme.0.0300151 AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
https://doi.org/10.1074/jbc.274.48.33881 Glutathione Levels Discriminate between Oxidative Stress and Transforming Growth Factor-β Signaling in Activated Rat Hepatic Stellate Cells
https://doi.org/10.1210/en.2002-221112 Specific and Combined Effects of Insulin and Glucose on Functional Pancreatic β-Cell Mass in Vivo in Adult Rats
https://doi.org/10.1136/gut.2003.036053 Expression of somatostatin receptors in normal and cirrhotic human liver and in hepatocellular carcinoma
https://doi.org/10.1177/002215540305100601 Nestin Is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas
https://doi.org/10.1006/excr.2002.5577 Trichostatin A, a Histone Deacetylase Inhibitor, Suppresses Collagen Synthesis and Prevents TGF-β1-Induced Fibrogenesis in Skin Fibroblasts
https://doi.org/10.1016/s0006-2952(03)00445-3 The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue
https://doi.org/10.1002/hep.20015 Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
https://doi.org/10.1086/318159 Acute Onset of Type I Diabetes Mellitus after Severe Echovirus 9 Infection: Putative Pathogenic Pathways
https://doi.org/10.1007/s00125-002-0949-8 IA-2 autoantibodies predict impending Type I diabetes in siblings of patients
https://doi.org/10.1007/s00125-009-1618-y Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2β) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials
https://doi.org/10.1002/hep.24238 Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
https://doi.org/10.1007/s00125-005-1959-0 Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes
https://doi.org/10.1016/s0168-8278(03)00051-5 Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
https://doi.org/10.1016/j.jhep.2003.12.006 On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal?
https://doi.org/10.1038/sj.bjp.0707189 Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
https://doi.org/10.1053/jhep.2001.21045 Formation of Normal Desmin Intermediate Filaments in Mouse Hepatic Stellate Cells Requires Vimentin
https://doi.org/10.1016/j.bbrc.2003.11.013 Prolonged culture in low glucose induces apoptosis of rat pancreatic β-cells through induction of c-myc
https://doi.org/10.1002/ijc.20481 Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis
https://doi.org/10.1007/s00125-016-4125-y Immunogenicity of human embryonic stem cell-derived beta cells
https://doi.org/10.1111/j.1463-1326.2008.00941.x Restoring a functional β‐cell mass in diabetes
https://doi.org/10.1053/gast.2001.27971 Somatostatin suppresses endothelin-1–induced rat hepatic stellate cell contraction via somatostatin receptor subtype 1
https://doi.org/10.2337/db16-0641 Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
https://doi.org/10.1007/s00125-001-0724-2 - to: T. J. Wilkin (2001) The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes. Diabetologia 44: 914–921
https://doi.org/10.1016/j.semcdb.2010.07.007 Pancreatic beta-cells: From generation to regeneration
https://doi.org/10.1111/j.1742-4658.2007.06131.x Peroxisome proliferator‐activated receptor α–retinoid X receptor agonists induce beta‐cell protection against palmitate toxicity
https://doi.org/10.1371/journal.pone.0007266 Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase
https://doi.org/10.1371/journal.pone.0043959 Beta Cell Count Instead of Beta Cell Mass to Assess and Localize Growth in Beta Cell Population following Pancreatic Duct Ligation in Mice
https://doi.org/10.1007/s00125-004-1426-3 Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells
https://doi.org/10.2337/db07-1705 Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor
https://doi.org/10.1111/j.1365-2249.2012.04675.x Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients
https://doi.org/10.1007/s00125-020-05317-y A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes
https://doi.org/10.1007/s00125-010-1851-4 Contribution of postnatally formed small beta cell aggregates to functional beta cell mass in adult rat pancreas
https://doi.org/10.1136/bmjopen-2015-007689 Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol
https://doi.org/10.1371/journal.pone.0060030 Evaluation of the INS-1 832/13 Cell Line as a Beta-Cell Based Screening System to Assess Pollutant Effects on Beta-Cell Function
https://doi.org/10.1371/journal.pone.0081071 Association of Cytokine and Toll-Like Receptor Gene Polymorphisms with Severe Malaria in Three Regions of Cameroon
https://doi.org/10.1016/j.bcp.2008.02.019 Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
https://doi.org/10.1002/hep.1840220139 The role of Kupffer cells in the differentiation process of hepatic natural killer cells
https://doi.org/10.1111/j.1365-2249.2008.03812.x Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation
https://doi.org/10.1111/jch.13225 Genetic factors contributing to hypertension in African‐based populations: A systematic review and meta‐analysis
https://doi.org/10.1007/s00125-010-1721-0 Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity
https://doi.org/10.5487/tr.2019.35.3.241 Gestational Exposure to Pesticides Induces Oxidative Stress and Lipid Peroxidation in Offspring that Persist at Adult Age in an Animal Model
https://doi.org/10.1152/ajpendo.00459.2006 Glucagon-like peptide-1 stimulates GABA formation by pancreatic β-cells at the level of glutamate decarboxylase
https://doi.org/10.1007/s43188-019-00028-y Metabolic effects of exposure to pesticides during gestation in female Wistar rats and their offspring: a risk factor for diabetes?
https://doi.org/10.1016/j.diabres.2016.01.003 Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses
https://doi.org/10.1097/tp.0b013e3182a6ee41 Omentum Is Better Site Than Kidney Capsule for Growth, Differentiation, and Vascularization of Immature Porcine β-Cell Implants in Immunodeficient Rats
https://doi.org/10.1007/s10964-019-01180-2 The Social Context and Illness Identity in Youth with Type 1 Diabetes: A Three-Wave Longitudinal Study
https://doi.org/10.1002/hep.22346 Multidrug resistance–associated proteins are crucial for the viability of activated rat hepatic stellate cells†‡
https://doi.org/10.1007/s11892-017-0925-9 Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants
https://doi.org/10.1080/08870446.2016.1144753 Coping with type 1 diabetes through emerging adulthood: Longitudinal associations with perceived control and haemoglobin A1c
https://doi.org/10.1016/s0168-8278(01)00081-2 Vascular endothelial growth factor and liver regeneration
https://doi.org/10.1111/obr.12260 Genetic association studies of obesity in Africa: a systematic review
https://doi.org/10.1007/s00125-013-3034-6 Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans